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[1]宁小菊,刘 剑,李燕妮,等.碘 125 放射性粒子植入联合消癌平注射液治疗中晚期肺癌的临床疗效[J].宁夏医科大学学报,2021,(02):133-136.[doi:10.16050/j.cnki.issn1674-6309.2021.02.006]
 NING Xiaoju,LIU Jian,LI Yanni,et al.Clinical Efficacy of Iodine 125 Radioactive Seed Implantation Combined with Xiaoaiping Injection in the Treatment of Advanced Lung Cancer[J].Ningxia Medical University,2021,(02):133-136.[doi:10.16050/j.cnki.issn1674-6309.2021.02.006]
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碘 125 放射性粒子植入联合消癌平注射液治疗中晚期肺癌的临床疗效(PDF)
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《宁夏医科大学学报》[ISSN:1005-8486/CN:64-1029/R]

卷:
期数:
2021年02期
页码:
133-136
栏目:
临床医学
出版日期:
2021-02-28

文章信息/Info

Title:
Clinical Efficacy of Iodine 125 Radioactive Seed Implantation Combined with Xiaoaiping Injection in the Treatment of Advanced Lung Cancer
文章编号:
1674-6309(2021)02-0133-04
作者:
宁小菊1 刘 剑2 李燕妮1 李晓龙1 雷光焰3 张春仙1 贾婷婷1
(1. 宁夏回族自治区中医医院暨中医研究院,银川 750021; 2. 宁夏医科大学总医院,银川 750004;3. 陕西省肿瘤医院,西安 710061)
Author(s):
NING Xiaoju1 LIU Jian2 LI Yanni1 LI Xiaolong1 LEI Guangyan3ZHANG Chunxian1 JIA Tingting1
(1. Ningxia Hui Autonomous Region Hospital of Traditional Chinese Medicine and Research Institute of Traditional Chinese Medicine, Yinchuan 750021,China; 2. General Hospital of Ningxia Medical University,Yinchuan 750004,China; 3. Shanxi Cancer Hospital,Xi’an 710061,China)
关键词:
碘125放射性粒子消癌平注射液中晚期肺癌
Keywords:
iodine 125 radioactive particlesXiaoaiping injectionadvanced lung cancer
分类号:
R734.2
DOI:
10.16050/j.cnki.issn1674-6309.2021.02.006
文献标志码:
A
摘要:
目的 探讨碘125放射性粒子植入联合消癌平注射液治疗中晚期肺癌的临床疗效。方法 选择2015年6月至2019年6月收治的中晚期肺癌患者64例,随机分为观察组32例与对照组32例。对照组患者采用碘125放射性粒子植入治疗,观察组患者在对照组基础上结合消癌平注射液治疗。两组疗程均为4周。比较两组近期疗效,治疗前后KPS评分、肿瘤标记物和免疫功能变化及不良反应发生情况。结果 两组患者治疗后KPS评分均较治疗前增加,观察组患者治疗后KPS评分高于对照组(P<0.05);两组患者治疗后血清CEA和CA125水平较治疗前降低,观察组患者治疗后血清CEA和CA125水平均低于对照组(P均<0.05);观察组患者治疗后CD3、CD4和CD4/CD8均较治疗前增加,观察组治疗后CD3、CD4和CD4/CD8均高于对照组(P均<0.05);两组患者治疗期间不良反应发生率差异无统计学意义(P>0.05)。结论 碘125放射性粒子植入联合消癌平注射液治疗中晚期肺癌患者近期疗效良好,可提高患者生存质量,降低肿瘤标记物血清CEA和CA125水平,提高患者免疫功能,且不良反应少。
Abstract:
Objective To investigate the clinical efficacy of iodine 125 radioactive seeds implantation combined with Xiaoaiping injection in the treatment of advanced lung cancer. Methods Sixty-four patients with advanced lung cancer in our hospital from June 2015 to June 2019 were selected and randomly divided into observation group(32 cases)and control group(32 cases)according to the random number table method.The control group was treated with iodine 125 radioactive seeds implantation,while the observation group was treated with Xiaoaiping injection on the basis of the control group.The course of treatment was 4 weeks in both groups.The short-term efficacy,KPS score,tumor markers and immune function changes before and after treatment,and the incidence of adverse reactions were compared between the two groups. Results KPS scores of two groups were significantly increased after treatment,KPS score of observation group was significantly higher than that of control group(P<0.05). Serum CEA and CA125 levels of two groups after treatment were lower than those before treatment,serum CEA and CA125 levels of observation group were lower than those of control group(P all<0.05). CD3,CD4 and CD4/CD8 ratio of two groups before treatment were lower than those of control group,CD3,CD4 and CD4/CD8 in the observation group increased after treatment(P all<0.05). CD3,CD4 and CD4/CD8 in the observation group were higher than those in the control group(P all<0.05). There was no statistical difference of the incidence of adverse reaction in two groups(P>0.05). Conclusion Iodine 125 radioactive seeds implantation combined with Xiaoaiping injection has a good short-term effect in the treatment of patients with advanced lung cancer,which can improve the quality of life of patients,reduce the serum CEA and CA125 levels of tumor markers,improve the immune function of patients,and has fewer adverse reactions.

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相似文献/References:

[1]马科,马立凤,牛阳,等.回药爱康方治疗中晚期原发性肺癌30例效果评价[J].宁夏医科大学学报,2009,(02):256.

备注/Memo

备注/Memo:
收稿日期:2020-01-14
作者简介:宁小菊,女,副主任医师,从事恶性肿瘤及内科常见病、疑难杂症的中药治疗及中西医结合治疗工作。
更新日期/Last Update: 1900-01-01