|本期目录/Table of Contents|

[1]张 静,李 芹,陈 辉,等.流式细胞术检测急性白血病微小残留病变68例临床分析[J].宁夏医科大学学报,2019,(12):1288-1290.[doi:10.16050/j.cnki.issn1674-6309.2019.12.024]
 ZHANG Jing,LI Qin,CHEN Hui,et al.Clinical Analysis of 68 Cases of Minimal Residual Disease in Acute Leukemia Detected by Flow Cytometry[J].Ningxia Medical University,2019,(12):1288-1290.[doi:10.16050/j.cnki.issn1674-6309.2019.12.024]
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流式细胞术检测急性白血病微小残留病变68例临床分析(PDF)
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《宁夏医科大学学报》[ISSN:1005-8486/CN:64-1029/R]

卷:
期数:
2019年12期
页码:
1288-1290
栏目:
经验交流
出版日期:
2020-03-27

文章信息/Info

Title:
Clinical Analysis of 68 Cases of Minimal Residual Disease in Acute Leukemia Detected by Flow Cytometry
文章编号:
1674-6309(2019)12-1288-03
作者:
张 静12 李 芹12 陈 辉12 朴文花12
(1. 宁夏回族自治区人民医院,银川 750002; 2. 西北民族大学第一临床医院,兰州 730000)
Author(s):
ZHANG Jing12 LI Qin12 CHEN Hui12 PIAO Wenhua12
(1. People’s Hospital of Ningxia Hui Autonomous Region,Yinchuan 750002,China; 2. First Clinical Hospital of Northwest University for Nationalities,Lanzhou 730000,China )
关键词:
急性白血病 流式细胞术微小残留病变 临床应用
Keywords:
acute leukemiaflow cytometryminimal residual diseaseclinical application
分类号:
R733.7
DOI:
10.16050/j.cnki.issn1674-6309.2019.12.024
文献标志码:
B
摘要:
目的 研究流式细胞术检测急性白血病微小残留病变的临床应用价值。方法 应用四色流式细胞术对2017年2月至2018年11月在我院血液科确诊后的68例急性白血病患者骨髓标本进行微小残留病变检测。结果 急性髓细胞白血病50例,急性淋巴细胞白血病18例。白血病相关免疫表型髓系异常以跨期表达多见,淋系异常以表达过量多见。对诱导化疗后患者,长期化疗并定期监测白血病微小残留病变原始细胞比例<0.1%的患者病情控制相对稳定,生存时间更长。结论 运用流式细胞术检测急性白血病微小残留病变对监测评估病情、评价疗效、提早预防复发和调整治疗方案有临床指导意义。
Abstract:
Objective To analyze the clinical application value of flow cytometry(FCM) in the detection of minimal residual disease(MRD) in acute leukemia. Methords A total of 68 patients born marrow with acute leukamia from February 2017 to November 2018 after diagnosis in our hematology department were examined by four-color flow cytometry. Results There were 50 cases of acute myeloid leukemia ,18 cases of lymphocytic leukemia.Leukemia - associated immunophenotype(LAIP) myeloid abnormalities were more common with intertemporal expression. Abnormal and excessive expression of the lymphatic system in leukemia-related immunophenotypes was common. For patients with long-term chemotherapy and regular monitoring of the proportion of primary cells <0.1% after induction of chemotherapy,the disease control was relatively stable and longer survival. Conclusion The application of flow cytometry to detect minimal residual disease in leukemia is of great significance in monitoring and evaluating the condition,evaluating the curative effect,preventing relapse in advance and adjusting the prescription of therapy.

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备注/Memo

备注/Memo:
收稿日期:2019-03-23
作者简介:张静(1979-),女,宁夏人,硕士,主治医师,从事临床血液病理工作。
更新日期/Last Update: 2019-12-30