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[1]马 斌,马金莲,闫小刚,等.多学科诊疗模式下新辅助化疗在进展期胃癌中的疗效观察[J].宁夏医科大学学报,2019,(12):1237-1239.[doi:10.16050/j.cnki.issn1674-6309.2019.12.010]
 MA Bin,MA Jinlian,YAN Xiaogang,et al.Influence of Neo-adjuvant Chemotherapy on Progressive Gastric Cancer Operation with Multi-disciplinary Team[J].Ningxia Medical University,2019,(12):1237-1239.[doi:10.16050/j.cnki.issn1674-6309.2019.12.010]
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多学科诊疗模式下新辅助化疗在进展期胃癌中的疗效观察(PDF)
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《宁夏医科大学学报》[ISSN:1005-8486/CN:64-1029/R]

卷:
期数:
2019年12期
页码:
1237-1239
栏目:
经验交流
出版日期:
2020-03-27

文章信息/Info

Title:
Influence of Neo-adjuvant Chemotherapy on Progressive Gastric Cancer Operation with Multi-disciplinary Team
文章编号:
1674-6309(2019)12-1237-04
作者:
马 斌 马金莲 闫小刚 张少华 杨晓君
(宁夏医科大学第二附属医院,银川 750001)
Author(s):
MA Bin MA Jinlian YAN Xiaogang ZHANG Shaohua YANG Xiaojun
(The Second Affiliated Hospital of Ningxia Medical University,Yinchuan 750001,China)
关键词:
多学科协作进展期胃癌替吉奥奥沙利铂新辅助化疗
Keywords:
multi-disciplinary teamadvanced gastric cancerS-1oxaliplatinneo-adjuvant chemotherapy
分类号:
R735.2
DOI:
10.16050/j.cnki.issn1674-6309.2019.12.010
文献标志码:
B
摘要:
目的 探讨在多学科协作(multi-disciplinary team,MDT)诊疗模式下,新辅助化疗对局部进展期胃癌手术疗效的影响。方法 选取2010年1月至2018年9月本院确诊的局部进展期胃癌患者190例,随机分为MDT组78例和非MDT组112例。MDT组在MDT模式诊疗下采用替吉奥(S-1)联合奥沙利铂(SOX)方案新辅助化疗治疗,非MDT组未在MDT诊疗模式下采用SOX方案治疗。比较两组患者的手术切除率、显微镜下无残留(R0)切除率、术后病理分期(PTNM)、复发转移及死亡情况。结果 MDT组的R0切缘阳性率(6.4%)低于非MDT组(33.0%)(P<0.05),MDT组的术后PTNM分期Ⅰ、Ⅱ期(70.6%)高于非MDT组(34.0%)(P<0.05),MDT组根治性切除率(87.2%)高于非MDT组(65.2%)(P<0.05)。MDT组肿瘤复发转移率(20.5%)低于非MDT组(44.6%)(P<0.05),MDT组病死率(9.0%)低于非MDT组(26.8%)(P<0.05)。结论 MDT诊疗模式下联合SOX方案新辅助化疗能提高局部进展期胃癌手术切除率、R0切除率,降低局部进展期胃癌复发转移及病死率。
Abstract:
Objective To explore the effect of neoadjuvant chemotherapy on the surgical outcome of locally advanced gastric cancer under the multi-disciplinary team(MDT). Methods A total of 190 patients with locally advanced gastric cancer diagnosed in our hospital from January 2010 to September 2018 were randomly divided into the MDT group(n=78) and the non-MDT group(n=112). MDT group: S-1 combined with oxaliplatin (SOX) regimen as neoadjuvant chemotherapy and adjuvant chemotherapy before and after surgery under the MDT; non-MDT group: S-1 combined with oxaliplatin(SOX) regimen as neoadjuvant chemotherapy after surgery without the MDT. The surgical resection rate, R0 resection rate, postoperative pathological stage, recurrence and metastasis and death were compared between the two groups. Results The positive rate of R0 resection margin in the MDT group was 6.4%, which was significantly lower than that in the non-MDT group. The positive rate of R0 resection was 33.0%. There was significant difference between the two groups(P<0.05). The postoperative PTNM stage I and Ⅱof the MDT group were 70.6%, which was significantly higher than that of the non-MDT group. In the MDT group, the PTNMI stage I and Ⅱ accounted for 34.0%, and the statistical difference was significant(P<0.05). The radical resection rate of the MDT group was 87.2%, which was significantly higher than that of the non-MDT group (65.2%). There was significant difference between the two groups. The recurrence and metastasis rate of MDT group was 20.5%, which was significantly lower than that of non-MDT group(44.6%). There was significant difference between the two groups(P<0.05). The mortality of MDT group was 9.0%, which was significantly lower than that of non-MDT group(26.8%)(P<0.05). Conclusion MDT combined with SOX regimen can improve the resection rate and R0 resection rate of locally advanced gastric cancer, and reduce the recurrence, metastasis and mortality of locally advanced gastric cancer.

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备注/Memo

备注/Memo:
收稿日期:2019-07-18
基金项目:宁夏科技支撑项目(2015BY093);宁夏医科大学科学研究基金项目(XM2015048)
作者简介:马斌(1976-),男,宁夏人,博士,副主任医师,从事消化道肿瘤的临床及研究。
通信作者:杨晓君,硕士,主任医师。E-mail:niuwa610@163.com
更新日期/Last Update: 2019-12-30