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[1]王 锐,闫 琳,赵迅霞,等.水杨酸伪麻黄碱对小鼠脑皮层电图的影响[J].宁夏医科大学学报,2019,(12):1207-1210.[doi:10.16050/j.cnki.issn1674-6309.2019.12.004]
 WANG Rui,YAN Lin,ZHAO Xunxia,et al.Effects of Pseudo-ephedrine Salicylate on Central Nervous System by Electrocorticogram in Mice[J].Ningxia Medical University,2019,(12):1207-1210.[doi:10.16050/j.cnki.issn1674-6309.2019.12.004]
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《宁夏医科大学学报》[ISSN:1005-8486/CN:64-1029/R]

卷:
期数:
2019年12期
页码:
1207-1210
栏目:
论著
出版日期:
2020-03-27

文章信息/Info

Title:
Effects of Pseudo-ephedrine Salicylate on Central Nervous System by Electrocorticogram in Mice
文章编号:
1674-6309(2019)12-1207-04
作者:
王 锐1 闫 琳2 赵迅霞2 王红燕3 卢宁清2 赵玉萍1 林 枫14
(1. 宁夏医科大学药学院药理学系,生育力保持教育部重点实验室,银川 750004; 2. 宁夏医科大学基础医学实验教学示范中心机能实验中心,银川 750004; 3. 宁夏医科大学总医院宁夏人类精子库,银川 750004; 4. 宁夏大学化学化工学院,银川 750021)
Author(s):
WANG Rui1 YAN Lin2 ZHAO Xunxia2 WANG Hongyan3 LU Ningqing3ZHAO Yuping1 LIN Feng14
1.Department of Pharmacology,School of Pharmacy,Key Laboratory of Ministry of Education in Fertility Preservation and Maintenance,Ningxia Medical University, Yinchuan 750004,China; 2. Functional Experimental Teaching Center of Basic Medical Science, Ningxia Medical University, Yinchuan 750004,China;3. Ningxia Human Sperm Bank, the General Hospital of Ningxia Medical University, Yinchuan 750004, China;4. School of Chemistry and Chemical Engineering, Ningxia University,Yinchuan 750021,China)
关键词:
水杨酸伪麻黄碱脑皮层电图总功率频率分配
Keywords:
pseudo-ephedrine salicylateelectrocorticogramspectrumfrequency distribution
分类号:
R96
DOI:
10.16050/j.cnki.issn1674-6309.2019.12.004
文献标志码:
A
摘要:
目的 探讨水杨酸伪麻黄碱对小鼠皮层脑电活动的影响。方法 40只小鼠随机分为4组,分别腹腔注射水杨酸伪麻黄碱25、50、100 mg·kg-1和生理盐水,采用电生理学方法测定小鼠脑皮层电图总功率(T)、主波频率及频率分配。结果 水杨酸伪麻黄碱25 mg·kg-1组可使小鼠脑皮层电图主波频率在给药后15、30、60、90、120 min 升高(P均<0.05);50 mg·kg-1组可使主波频率仅在给药后5 min升高(P<0.05)。水杨酸伪麻黄碱25 mg·kg-1组给药后5 和90 min时可使(α+β)/ T升高,(δ+θ)/ T降低(P均<0.05);50 mg·kg-1 组在给药后120 min时(δ+θ)/ T降低(P<0.05);100 mg·kg-1组给药后30min时可致δ / T升高(P<0.05),给药后5、15和60 min时θ / T降低(P均<0.05)。各剂量组水杨酸伪麻黄碱对脑电总功率均无明显影响(P均>0.05)。结论 水杨酸伪麻黄碱在低剂量时中枢神经兴奋性增强。
Abstract:
Objective To investigate the effects of Pseudo-ephedrine Salicylate(PES)on electrocorticogram(ECoG) in mice. Methods Total power, document frequency and frequency distribution were used to observe the change of ECoG in mice administrated with PES. Results Compared with normal saline group, document frequency of the PES(25 mg·kg-1) treated group was significantly increased after administration 15, 30, 60, 90 and 120min(P all<0.05). After administration for 5min, document frequency of the PES(50 mg·kg-1) treated group was significantly increased. The ratio sum of α wave and β wave to total power in the PES(25 mg·kg-1) treated group was significantly increased(P<0.05), meanwhile the ratio sum of δ wave and θ wave to total power was decreased(P<0.05) after administration for 5 and 90 min. The ratio sum of δ wave and θ wave to total power in the PES(50 mg·kg-1) treated group was decreased(P all<0.05) after administration for 120min. The ratio δ wave to total power in PES(100 mg·kg-1) treated group was significantly increased(P<0.05)after administration for 5 min,15 min and 60 min,the ratio θ wave to total power in PES(100 mg·kg-1) treated group was decreased(P all<0.05). The total power was not changed in PES (25, 50 and 100 mg·kg-1) treated group(P all>0.05). Conclusion Only low dose of PES has excitability on central nervous system.

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备注/Memo

备注/Memo:
收稿日期:2019-03-26
基金项目:国家自然科学基金(81860640);宁夏自然科学基金(NZ17080)
作者简介:王锐,男,副教授。E-mail: dwl_email@163.com
通信作者:林枫,女,副教授。E-mail:Linf-002@163.com
更新日期/Last Update: 2019-12-30