|本期目录/Table of Contents|

[1]郝晓丽,程玉瑛.芪明颗粒联合激光光凝术治疗糖尿病视膜病变的临床观察[J].宁夏医科大学学报,2019,(06):593-597.[doi:10.16050/j.cnki.issn1674-6309.2019.06.011]
 HAO Xiaoli,CHENG Yuying.Clinical Observation on Qiming Granule in Combined with Laser Photocoagulation in the Treatment of DR[J].Ningxia Medical University,2019,(06):593-597.[doi:10.16050/j.cnki.issn1674-6309.2019.06.011]
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芪明颗粒联合激光光凝术治疗糖尿病视膜病变的临床观察(PDF)
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《宁夏医科大学学报》[ISSN:1005-8486/CN:64-1029/R]

卷:
期数:
2019年06期
页码:
593-597
栏目:
经验交流
出版日期:
2019-06-30

文章信息/Info

Title:
Clinical Observation on Qiming Granule in Combined with Laser Photocoagulation in the Treatment of DR
文章编号:
1674-6309(2019)06-0593-05
作者:
郝晓丽1 程玉瑛2
(1. 深州市医院眼科,衡水 053800; 2. 河北医科大学第一医院眼科,石家庄 050017)
Author(s):
HAO Xiaoli1 CHENG Yuying2
(1. Department of Ophthalmology, Shenzhou Hospital, Hengshui 053800,China; 2. Department of Ophthalmology, First Hospital of Hebei Medical University,Shijiazhuang 050017,China)
关键词:
DR芪明颗粒激光光凝术炎性因子新生血管
Keywords:
DRqiming granulelaser photocoagulationinflammatory cytokinenew blood vessel
分类号:
R587.2
DOI:
10.16050/j.cnki.issn1674-6309.2019.06.011
文献标志码:
B
摘要:
目的 探讨芪明颗粒联合激光光凝术治疗糖尿病视膜病变(DR)的临床疗效。方法 选取2017年6月-2018年5月医院收治的DR患者110例作为研究对象,随机分为观察及对照组各55例,两组患者均使用532眼底激光治疗仪治疗,观察组联合服用芪明颗粒。抽取两组患者治疗前及治疗3个月后空腹外周静脉血,采用酶联免疫吸附法(ELISA)测定血清肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)水平;采用免疫比浊法测定超敏C反应蛋白(hs-CRP)、血管生成素-2(Ang-2)、血管内皮生长因子(VEGF)。于治疗前、治疗1、3个月后检查最佳矫正视力,采用光学相干断层扫描仪(OCT)检查黄斑中心凹厚度(CMT)。结果 治疗3个月后两组患者血清TNF-α、IL-6、hs-CRP、Ang-2、VEGF均低于同组治疗前(P均<0.05);观察组治疗后血清TNF-α、IL-6、hs-CRP、Ang-2、VEGF均低于同期对照组(P均<0.05)。两组患者治疗前BCVA、CMT差异均无统计学意义(P均>0.05),治疗1、3个月后BCVA、CMT均低于同组治疗前(P均<0.05);观察组治疗1、3个月后BCVA、CMT均低于同期对照组(P均<0.05)。结论 芪明颗粒联合激光光凝术能够减轻机体炎症反应,降低Ang-2、VEGF水平,减少新生血管,提高治疗效果。
Abstract:
Objective To explore the effect of Qiming granule in combined with laser photocoagulation on the inflammatory cytokines and neovascularization index in patients with diabetic retinopathy(DR). Methods A total of 110 patients with DR who were admitted in our hospital from June,2017 to May,2018 were included in the study and randomized into the observation group and the control group with 55 cases in each group. The patients in the two groups were given 532 fundus laser therapeutic instrument. On the above basis, the patients in the observation group were given Qiming granules. Fasting peripheral venous blood was drawn from two groups before and after 3 months of treatment. The serum TNF-α,IL-6,hs-CRP,Ang-2,and VEGF were detected by ELISA. The international standard logarithmic visual acuity chart was used to examine BCVA before treatment,1 and 3 months after treatment. OCT was used to examine CMT. Results After 3 months of treatment,serum TNF-α,IL-6, hs-CRP,Ang-2 and VEGF were lower in the two groups than those of before treatment(P<0.05). Serum TNF-alpha, IL-6,hs-CRP,Ang-2 and VEGF in the observation group were lower than those in the control group after treatment(P<0.05). There were no significant differences in BCVA and CMT between the two groups(P>0.05). After 1 and 3 months of treatment, BCVA and CMT were lower than those in the same group(P<0.05). After 3 months, BCVA and CMT were lower than the control group (P<0.05). Conclusions Qiming granule in combined with laser photocoagulation in the treatment of DR can alleviate the inflammatory reaction,decrease Ang-2 and VEGF levels,reduce the new blood vessels,and improve the therapeutic effect.

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备注/Memo

备注/Memo:
收稿日期:2019-01-17
基金项目:河北省科学技术局项目(200940387-1)
作者简介:郝晓丽(1968-),女,学士,副主任医师,研究方向:临床眼科。
通信作者:程玉瑛,男,学士,主任医师,研究方向:临床眼科。 E-mail:yankehaoxiaoli@163.com
更新日期/Last Update: 2019-06-30