|本期目录/Table of Contents|

[1]王晶晶,谢 娟,顾晓静,等.失代偿期肝硬化合并感染相关因素的分析[J].宁夏医科大学学报,2018,(12):1395-13,971,403.[doi:10.16050/j.cnki.issn1674-6309.2018.12.007]
 WANG Jingjing,XIE Juan,GU Xiaojing,et al.Analysis of Related Factors of Decompensated Cirrhosis Complicated with Infection[J].Ningxia Medical University,2018,(12):1395-13,971,403.[doi:10.16050/j.cnki.issn1674-6309.2018.12.007]
点击复制

失代偿期肝硬化合并感染相关因素的分析(PDF)
分享到:

《宁夏医科大学学报》[ISSN:1005-8486/CN:64-1029/R]

卷:
期数:
2018年12期
页码:
1395-13,971,403
栏目:
论 著
出版日期:
2018-12-30

文章信息/Info

Title:
Analysis of Related Factors of Decompensated Cirrhosis Complicated with Infection
文章编号:
1674-6309(2018)12-1395-03
作者:
王晶晶1 谢 娟1 顾晓静1 王晓佳2 杨少奇1
(1. 宁夏医科大学总医院消化内科,银川 750004; 2. 宁夏医科大学总医院病案室,银川 750004)
Author(s):
WANG Jingjing1 XIE Juan1 GU Xiaojing1 WANG Xiaojia2 YANG Shaoqi1
(1. Department of Gastroenterology,General Hospital of Ningxia Medical University,Yinchuan 750004; 2. Medical Records Room,General Hospital of Ningxia Medical University,Yinchuan 750004)
关键词:
肝硬化失代偿期感染危险因素
Keywords:
cirrhosis decompensated period infection risk factor
分类号:
R575.2
DOI:
10.16050/j.cnki.issn1674-6309.2018.12.007
文献标志码:
A
摘要:
目的 分析失代偿期肝硬化患者合并感染的相关危险因素。方法 回顾总结297例失代偿期肝硬化合并感染患者(观察组)和279例同期收住未发生感染的失代偿期肝硬化患者(对照组)的临床资料,对2组的指标运用单因素和多因素Logistic回归模型进行分析。结果 病例组和对照组在住院时间、并发症、白细胞计数(WBC)、中性粒细胞相对值(NEUT)、血红蛋白(HGB)、血清钠、总胆红素(TBIL)、血清白蛋白(ALB)、凝血酶原时间(PT)、凝血酶原活动度(PTA)、国际标准化比值(INR)、纤维蛋白原(FIB)差异均有统计学意义(P均<0.01),与患者的性别、年龄、肝硬化病因、是否合并糖尿病和血小板计数(PLT)差异无统计学意义(P均>0.05)。进一步多因素非条件Logistic回归分析结果显示,住院时间、WBC、NEUT、血清钠、ALB是失代偿肝硬化患者感染的独立影响因素。结论 住院时间延长、WBC和NEUT升高、低钠血症、低蛋白血症是失代偿期肝硬化合并感染的独立危险因素。
Abstract:
Objective To summarize and analyze the risk factors of infection in patients with decompensated cirrhosis. Methods The clinical data of 297 patients with decompensated cirrhosis complicated with infection (observation group) and 279 patients with decompensated cirrhosis(control group) who were hospitalized without infection at the same time were retrospectively summarized. The differences between the two groups were analyzed by single factor and multifactor logistic regression model. Results There were significant differences in hospitalization time,complications,white blood cell count(WBC),neutrophil relative value(NEUT), hemoglobin (HGB),serum sodium, total bilirubin (TBIL),serum albumin (ALB),prothrombin time (PT), prothrombin activity (PTA),international standardized ratio (INR),fibrinogen (FIB) between the case group and the control group(P<0.01). There were no significant differences in gender,age,etiology of cirrhosis, diabetes mellitus and platelet count(PLT)(all P>0.05). Further multivariate unconditional logistic regression analysis showed that hospitalization time,WBC,NEUT,serum sodium and ALB were independent risk factors for infection in decompensated cirrhosis patients. Conclusion Extended hospitalization, increased WBC and NEUT,hyponatremia and hypoproteinemia were independent risk factors for decompensated cirrhosis complicated with infection.

参考文献/References:


[1] Yoneyama K,Miyagishi K,Kiuchi Y,et al. Risk factors for infections in cirrhotic patients with and without hepatocellular carcinoma[J]. J Gastroenterol,2002, 37(12):1028-1034.
[2] Borzio M,Salerno F,Piantoni L,et al. Bacterial infection in patients with advanced cirrhosis:a multicentre prospective study[J]. Dig Liver Dis,2001,33(1):41-48.
[3] Ghassemi S,Garcia-Tsao G. Prevention and treatment of infections in patients with cirrhosis[J]. Best Pract Res Clin Gastroenterol,2007,21(1):77-93.
[4] Arvaniti V,D'Amico G,Fede G,et al. Infections in patients with cirrhosis increase mortality four-fold and should be used in determining prognosis[J]. Gastroenterology,2010,139(4):1246-1256.
[5] Talwani R,Gilliam BL,Howell C. Infectious diseases and the liver[J]. Clin Liver Dis,2011,15(1):111-130.
[6] Ghassemi S,Garcia-Tsao G. Prevention and treatment of infections in patients with cirrhosis[J]. Best Pract Res Clin Gastroenterol,2007,21(1):77-93.
[7] Christou L,Pappas G,Falagas ME. Bacterial infection-related morbidity and mortality in cirrhosis[J].Am J Gastroenterol,2007,102(7):1510-1517.
[8] Navasa M,Rimola A,Rodés J. Bacterial infections in liver disease[J]. Semin Liver Dis,1997,17(4):323-333.

相似文献/References:

[1]王玉珍,苗玉兰,杨发强,等.益气聪明汤治疗慢性脑供血不足的临床观察[J].宁夏医科大学学报,2018,(12):1457.[doi:10.16050/j.cnki.issn1674-6309.2018.12.028]
[2]谢秋兰,张锦,张瑞,等.23例急性肺血栓栓塞症死亡病例临床分析[J].宁夏医科大学学报,2013,(06):691.
[3]胡丹凤,胡汉楚,霍小平,等.老年出血性消化性溃疡患者再出血危险因素分析[J].宁夏医科大学学报,2013,(05):585.
[4]袁 宁,周 丽,纳丽莎,等.缺血性二尖瓣关闭不全的危险因素探讨[J].宁夏医科大学学报,2013,(05):556.
[5]李晓萍,张 龙,刘 华.摩根摩根菌致肺内感染合并菌血症1例[J].宁夏医科大学学报,2013,(03):357.
[6]张 龙,李晓萍,刘 华.侵袭性肺曲霉菌病1例[J].宁夏医科大学学报,2013,(03):292.
[7]杨 炬,王 雯,高 洁,等.宁夏职业暴露人群和环境高致病性禽流感感染情况调查[J].宁夏医科大学学报,2013,(03):286.
 YANG Ju,WANG Wen,GAO Jie,et al.Investigation of Avian Influenza A Virus Infection among Occupational Exposed Population of Ningxia[J].Ningxia Medical University,2013,(12):286.
[8]肖金丽,徐 斌,夏 云,等.负压吸引系统在糖尿病足伴感染中的应用[J].宁夏医科大学学报,2013,(01):97.
[9]许红霞,张毓洪,刘 瑛,等.银川市农村青年人高血压患病率及危险因素分析[J].宁夏医科大学学报,2013,(01):63.
 XU Hong-xia,ZHANG Yu-hong,LIU Ying,et al.Prevalence and Risk Factors of Hypertension among Rural Young Adults in Yinchuan City[J].Ningxia Medical University,2013,(12):63.
[10]靳 峰,李 丽,宋晓佳,等.2010年宁夏布鲁氏菌病重点人群流行病学现况调查分析[J].宁夏医科大学学报,2013,(01):49.
 JIN Feng,LI Li,SONG Xiai-jia,et al.An Epidemiology Investigation of the Brucellosis in Key Population of Ningxia in 2010[J].Ningxia Medical University,2013,(12):49.
[11]王 艳,王海霞,马希刚.重症患者凝血指标对病情及预后的评价作用[J].宁夏医科大学学报,2013,(09):980.
 WANG Yan,WANG Haixia,MA Xigang.Evaluation Effect of Coagulation Indicators on the Severity and Prognosis of the Disease in Critically Ill Patients[J].Ningxia Medical University,2013,(12):980.

备注/Memo

备注/Memo:
收稿日期:2018-06-12
基金项目:宁夏回族自治区“十三五”重点研发计划(重大科技项目,2016BZ02)
作者简介:王晶晶(1983-),女(回族),银川人,主治医师,研究方向:肝脏疾病。
通信作者:杨少奇,男,博士,教授,硕士研究生导师。 E-mail:shaoqiynh@hotmail.com
更新日期/Last Update: 2018-12-30