|本期目录/Table of Contents|

[1]王志军,马俊丽,段丽娜,等.磁共振弥散张量成像在纹状体梗死后黑质继发损伤诊断中的应用[J].宁夏医科大学学报,2018,(08):899-902,906.[doi:10.16050/j.cnki.issn1674-6309.2018.08.007]
 WANG Zhijun,MA Junli,DUAN Lina,et al.Application of MRI Diffusion Tensor Imaging in the Diagnosis of Secondary Substantia Nigra Lesion in Striatum Infarction[J].Ningxia Medical University,2018,(08):899-902,906.[doi:10.16050/j.cnki.issn1674-6309.2018.08.007]
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磁共振弥散张量成像在纹状体梗死后黑质继发损伤诊断中的应用(PDF)
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《宁夏医科大学学报》[ISSN:1005-8486/CN:64-1029/R]

卷:
期数:
2018年08期
页码:
899-902,906
栏目:
论著
出版日期:
2018-08-30

文章信息/Info

Title:
Application of MRI Diffusion Tensor Imaging in the Diagnosis of Secondary Substantia Nigra Lesion in Striatum Infarction
文章编号:
1674-6309(2018)08-0899-04
作者:
王志军 马俊丽 段丽娜 张 薇 范琦璇
(宁夏医科大学总医院肿瘤医院放射科,银川 750004)
Author(s):
WANG Zhijun MA Junli DUAN Lina ZHANG Wei FAN Qixuan
(Department of Radiology, Cancer Hospital of the General Hospital, Ningxia Medical University,Yinchuan 750004)
关键词:
纹状体梗死黑质继发损伤弥散张量成像核磁共振
Keywords:
striatum infarction secondary lesion of substantia nigra difliusion tensor imaging MRI
分类号:
R816
DOI:
10.16050/j.cnki.issn1674-6309.2018.08.007
文献标志码:
A
摘要:
目的 评价磁共振弥散张量成像(diffusion tensor imaging,DTI)扫描在纹状体梗死后的黑质继发损害中的诊断价值及临床意义。方法 收集经颅脑核磁共振成像(magnetic resonance imaging,MRI)扫描确诊的单侧基底节区局灶性梗死累及纹状体的脑梗死患者30例,7~10d后复查颅脑MRI并行DTI检查,了解患者是否存在亚急性期黑质继发性损害改变。采用美国国立卫生研究院卒中评分(national institute of health stroke scale,NIHSS)及Barthol指数(barthel index,BI)评估量表系统评价脑梗死患者神经功能损伤程度及日常生活自理能力。比较纹状体梗死伴黑质继发性损害组与无继发性损害组表观平均弥散量(mean diffusivity,MD)和各向异性分数(fractional anisotropy,FA)的差别,分析MD和FA与临床评分的相关性。结果 36.67%(11例)的脑梗死患者亚急性期出现黑质继发损伤,其梗死灶同侧黑质MD值是无黑质损伤组的1.84倍(t=5.174,P= 0.000),两组FA值差异无统计学意义。MD值与NIHSS评分呈正相关(r=0.554,P=0.002),与BI指数呈负相关(r=-0.399,P=0.029)。结论 颅脑MRI及DTI扫描可对纹状体梗死后亚急性期黑质继发性损害程度进行定量测定,其中MD值对黑质继发损害患者病情及预后有一定评估价值。
Abstract:
Objective To evaluate the diagnostic value and clinical significance of diffusion tensor imaging (DTI)in secondary lesions of substantia nigra after striatum infarction. Methods Thirty patients with striatum-related cerebral infarction in unilateral basal ganglia region confirmed by transcranial magnetic resonance imaging(MRI) were enrolled. The brain MRI and DTI were examined 7-10 days later to find out if there were secondary nigra lesions in the patients. The neurological impairment and daily living ability of patients with cerebral infarction were evaluated by the national institutes of health stroke score(NIHSS) and Barthol Index(BI). The difference of mean diffusivity (MD) and fractional anisotropy (FA) between striatum infarction with and without secondary substantia nigra lesion were compared and the correlations between the DTI values and clinical scores were analyzed. Result Secondary lesion of substantia nigra occurred in 36.67% of cerebral infarction patients(11 cases) in subacute stage. Mean value of MD in the group of substantia nigra lesion was 1.84 folds of that in the group without nigra injury(t=5.174,P=0.000). Mean values of FA in the two groups had no statistical difference. MD value was positively correlated with NIHSS(r=0.554,P=0.002),and negatively correlated with BI (r=-0.399,P=0.029). Conclusion Brain MRI and DTI can quantitatively measure the degree of secondary nigra damage in subacute stage after striatum infarction,and MD value has certain evaluation value for the condition and prognosis of patients with secondary nigra damage.

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备注/Memo

备注/Memo:
收稿日期:2018-06-06
基金项目:宁夏自然科学基金(NZ16144)
作者简介:王志军(1978-),男,副主任医师,硕士,研究方向:神经系统影像诊断及基础研究。
更新日期/Last Update: 2018-08-30