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[1]郝建坤.华蟾素对老年非小细胞肺癌患者血清相关细胞因子及肿瘤标志物的影响[J].宁夏医科大学学报,2018,(06):676-680.[doi:10.16050/j.cnki.issn1674-6309.2018.06.012]
 HAO Jiankun.Effect of Cinobufagin on the Serum Related Cytokines and Tumor Markers in Patients with Non-small-cell Lung Cancer[J].Ningxia Medical University,2018,(06):676-680.[doi:10.16050/j.cnki.issn1674-6309.2018.06.012]
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华蟾素对老年非小细胞肺癌患者血清相关细胞因子及肿瘤标志物的影响(PDF)
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《宁夏医科大学学报》[ISSN:1005-8486/CN:64-1029/R]

卷:
期数:
2018年06期
页码:
676-680
栏目:
论著
出版日期:
2018-06-30

文章信息/Info

Title:
Effect of Cinobufagin on the Serum Related Cytokines and Tumor Markers in Patients with Non-small-cell Lung Cancer
作者:
郝建坤
(河北省冀中能源峰峰集团总医院急诊科,邯郸 056200)
Author(s):
HAO Jiankun
(Department of Emergency, Jizhong Energy Resources Fengfeng Group General Hospital in Hebei Province, Handan 056200)
关键词:
华蟾素非小细胞肺癌细胞因子肿瘤标志物
Keywords:
cinobufaginnon-small-cell lung cancercytokinetumor marker
分类号:
R734.2
DOI:
10.16050/j.cnki.issn1674-6309.2018.06.012
文献标志码:
A
摘要:
目的 探讨华蟾素对老年非小细胞肺癌(NSCLC)患者血清相关细胞因子及肿瘤标志物的影响。方法 选取2016年7月-2017年6月河北省冀中能源峰峰集团总医院收治的NSCLC患者74例为研究对象,随机分为观察组和对照组各37例,对照组采用NP化疗方案,观察组在对照组基础上联合华蟾素。治疗2个周期,采集治疗前、后患者晨起空腹外周静脉血,采用酶联免疫吸附法(ELISA)进行检测细胞因子白细胞介素-2(IL-2)、干扰素-γ(INF-γ)、肿瘤坏死因子-α(TNF-α)和白细胞介素-4(IL-4)、白细胞介素-10(IL-10),肿瘤标志物癌胚抗原(CEA)、细胞角蛋白19片段(CYFRA21-1)、神经元特异性烯醇化酶(NSE)、糖类抗原-125(CA125),血清指标P53抗体(P53)、缺氧诱导因子-1α(HIF-1α)、第十号染色体同源丢失性磷酸酶-张力蛋白基因(PTEN)。结果 治疗后IL-2较同组治疗前升高,INF-γ、TNF-α、IL-4、IL-10较同组治疗前降低(P<0.05),观察组治疗后IL-2高于对照组,INF-γ、TNF-α、IL-4、IL-10低于对照组(P均<0.01);治疗后CEA、CYFRA21-1、NSE、CA125较同组治疗前降低(P<0.05),观察组治疗后CEA、CYFRA21-1、NSE、CA125低于对照组(P<0.01);治疗后P53、HIF-1α较同组治疗前降低,PTEN较同组治疗前升高(P>0.05),观察组治疗后P53、HIF-1α低于对照组,PTEN高于对照组(P<0.01)。结论 华蟾素对老年NSCLC患者具有明显抗癌及免疫调节作用,可有效抑制癌细胞的增殖与分化,减弱肿瘤细胞免疫抑制效应,降低肿瘤标志物水平。
Abstract:
Objective To explore the effect of cinobufagin on the serum related cytokines and tumor markers in patients with non-small-cell lung cancer(NSCLC). Methods A total of 74 patients with NSCLC were admitted in our hospital from July 2016 to June 2017 were included in the study and randomized divided into the observation group and the control group with 37 cases in each group. The patients in the control group were given NP chemotherapy regimen. On the above basis,the patients in the observation group were given cinobufagin. 2 weeks later,the morning fasting peripheral venous blood before and after treatment was collected. ELISA was used to detect IL-2,INF-γ,TNF-α,IL-4,IL-10,CEA,CYFRA21-1,NSE,CA125,P53,HIF-1α,and PTEN. Results IL-2 after treatment in the observation group was significantly higher than that in the control group, while INF-γ,TNF-α,IL-4,and IL-10 were significantly lower than those in the control group(P<0.01). CEA,CYFRA21-1,NSE,and CA125 in the observation group after treatment were significantly lower than those in the control group(P<0.01). P53 and HIF-1α after treatment in the observation group were significantly lower than those in the control group,while PTEN was significantly higher than that in the control group(P<0.01). Conclusion Cinobufagin has an obviously anti-cancer and immunoregulation effect in patients with NSCLC,can effectively inhibit the proliferation and differentiation of cancer cells, weaken the immunosuppression of tumor cells, and reduce the levels of tumor markers.

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备注/Memo

备注/Memo:
收稿日期:2017-12-09
作者简介:郝建坤(1976-),男,学士,主治医师,研究方向:急诊医学。E-mail:fzryszclw@163.com
更新日期/Last Update: 2018-06-30