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[1]侯绍章,张婷,李媛,等.胃腺癌中Ki-67、HER2、P53、CEA、HIF-1α、EGFR和VEGF的表达及意义[J].宁夏医科大学学报,2017,(11):1267-1271.[doi:10.16050/j.cnki.issn1674-6309.2017.11.007]
 HOU Shaozhang,ZHANG Ting,LI Yuan,et al.The Significance and Expression of Ki-67,HER2,P53,CEA,HIF-1α,EGFR and VEGF in Gastric Adenocarcinoma[J].Ningxia Medical University,2017,(11):1267-1271.[doi:10.16050/j.cnki.issn1674-6309.2017.11.007]
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《宁夏医科大学学报》[ISSN:1005-8486/CN:64-1029/R]

卷:
期数:
2017年11期
页码:
1267-1271
栏目:
论著
出版日期:
2017-11-30

文章信息/Info

Title:
The Significance and Expression of Ki-67,HER2,P53,CEA,HIF-1α,EGFR and VEGF in Gastric Adenocarcinoma
作者:
侯绍章1张婷1李媛2贺茂涛3伍智慧1
1.宁夏医科大学基础医学院病理学系,银川 750004; 2.宁夏医科大学护理学院,银川 750004; 3.宁夏医科大学总医院病理科,银川 750004
Author(s):
HOU Shaozhang1ZHANG Ting1LI Yuan2HE Maotao3WU Zhihui1
1. Department of Pathology,School of Basic Medical Sciences,Ningxia Medical University, Yinchuan 750004; 2. Department of Nursing,Ningxia Medical University,Yinchuan 750004; 3. Department of Pathology,the General Hospital of Ningxia Medical University,Yinchuan 750004
关键词:
胃腺癌免疫组织化学HER2Ki-67P53CEA
Keywords:
gastric adenocarcinoma immunohistochemistryHER2 Ki-67P53 CEA
分类号:
R735.2
DOI:
10.16050/j.cnki.issn1674-6309.2017.11.007
文献标志码:
A
摘要:
目的 探讨胃腺癌中Ki-67、HER2、P53、CEA、HIF-1α、EGFR和VEGF的表达及各指标之间的关联。方法 通 过免疫组织化学法检测262例胃腺癌组织中增殖细胞相关的核抗原(Ki-67)、原癌基因人类表皮生长因子受体2( HER2)、肿瘤抑制基因P53(P53)、癌胚抗原(CEA)、低氧诱导因子-1α(HIF-1α)、表皮生长因子受体 (EGFR)和血管内皮生长因子(VEGF)的表达,分析各指标之间的相关性。结果 TNM分期Ⅰ、Ⅱ期胃腺癌组织中 Ki-67、EGFR阳性表达率低于Ⅱ、Ⅲ期(P<0.05);农民、无神经侵犯的胃腺癌组织中HER2阳性表达率高于从事 其他职业及有神经侵犯者(P<0.05),不同分化程度和Lauren’s 分型的胃腺癌组织中HER2阳性表达率差异有统 计学意义(P<0.05);无神经侵犯的胃腺癌组织中P53阳性表达率高于有神经侵犯者(P<0.05);无淋巴结转移 及TNM分期Ⅰ、Ⅱ期的胃腺癌组织中CEA阳性表达率低于有转移者和TNM分期Ⅱ、Ⅲ期者(P<0.05);不同Lauren ’s 分型的胃腺癌组织中VEGF阳性表达率差异有统计学意义,无淋巴结转移的胃腺癌组织中EGFR和VEGF阳性表达 率均低于有转移者(P<0.05)。HER2与Ki-67、VEGF的表达呈正相关,CEA与P53、EGFR和VEGF表达呈正相关, EGFR和VEGF表达呈正相关(P<0.05)。结论 检测Ki-67、HER2、P53、CEA、EGFR和VEGF在胃腺癌组织中的表达对 胃腺癌的诊断、治疗及预后判断有一定临床价值。
Abstract:
Objective To investigate expression and its clinical significance of Ki-67,HER2,P53, CEA,HIF-1α,EGFR and VEGF in gastric adenocarcinoma. Methods The expression of Ki-67,HER2,P53 ,CEA,HIF-1α,EGFR and VEGF was detected by immunohistochemistry in gastric adenocarcinoma tissues of 262 cases. Results The expression of HER2 was statistically associated with different histological grading group,the Lauren classification,and nerve invasion in the gastric adenocarcinoma. The expression of Ki-67 was significantly correlated with TNM staging. The expression of P53 protein was significantly correlated with nerve invasion. The expression of CEA protein and VEGF protein was positively correlated with lymph node metastasis and TNM staging. The expression of VEGF protein was positively correlated with Lauren classification and lymph node metastasis. HER2 protein was positively correlated with VEGF and Ki-67 protein expression. The expression of CEA protein was positively correlated with EGFR,VEGF and P53 protein expression. The expression of EGFR protein was positively correlated with VEGF protein expression. The expression of HIF-1α was not correlated with clinicopathological features and any other immunohistochemical indexes. Conclusion There was a close association between the abnormal expression and the occurrence and progression of gastric adenocarcinoma,there were complex relationship among Ki-67 ,HER2,P53,CEA,EGFR and VEGF,the co-detection of these proteins might have important value for diagnosis and the estimate of prognosis of the disease. The expression of HIF-1α in gastric adenocarcinoma is less valuable in diagnosis and prognosis,and needs further study. This study provides a basis for further study on the occurrence and development of gastric adenocarcinoma.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2017-07-24
基金项目:国家自然科学基金(81160106);宁夏自然科学基金(NZ17053);宁夏医科大学基础医学西部一流学 科建设项目(201-30181602);宁夏医科大学校级科研项目(XM2016028)
作者简介:侯绍章(1975-),男,博士,副教授,主要从事糖尿病肾病及肿瘤基础和临床研究。E-mail: 444588403@qq.com
更新日期/Last Update: 1900-01-01