|本期目录/Table of Contents|

[1]程方,赵君利,陆宏,等.女性指长比与卵巢早衰关联性研究[J].宁夏医科大学学报,2017,(11):1263-1266.[doi:10.16050/j.cnki.issn1674-6309.2017.11.006]
　CHENG Fang,ZHAO Junli,LU Hong,et al.The Assiociation of the Digit Ratio and Premature Ovarian Failure[J].Ningxia Medical University,2017,(11):1263-1266.[doi:10.16050/j.cnki.issn1674-6309.2017.11.006]
点击复制

女性指长比与卵巢早衰关联性研究(PDF)
分享到：

《宁夏医科大学学报》[ISSN:1005-8486/CN:64-1029/R]

卷:
期数:
2017年11期
页码:
1263-1266
栏目:
论著
出版日期:
2017-11-30

文章信息/Info

Title:
The Assiociation of the Digit Ratio and Premature Ovarian Failure
作者:
程方1; 赵君利2; 3; 陆宏3; 刘丹4; 杜娟1
1. 宁夏银川市妇幼保健院生殖医学中心，银川 750001； 2. 宁夏医科大学总医院生殖医学中心， 银川 750004； 3. 宁夏医科大学生育力保持教育部重点实验室，银川 750004； 4. 第四军医大学唐都医院生殖医学中心，西安 710038
Author(s):
CHENG Fang1; ZHAO Junli2; 3; LU Hong2; LIU Dan1; DU Juan1
1. Center for Reproductive Medicine，Yinchuan Women and Children Health Care Hospital，Yinchuan 750001； 2. Reproductive Medicine Center，the General Hospital of Ningxia Medical University，P.R Yinchuan 750004； 3. Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education，Ningxia Medical University， Yinchuan 750004； 4. Center for Reproductive Medicine ，Department of Obstetrics and Gynecology，Tangdu Hospital，The Fourth Military Medical University，Xi’an 710038
关键词:
指长比; 卵巢早衰; 不孕
Keywords:
digit ratio;  premature ovarian failure;  infertility
分类号:
R711.75
DOI:
10.16050/j.cnki.issn1674-6309.2017.11.006
文献标志码:
A
摘要:
目的 探讨人类指长比与卵巢早衰（POF）的关系。方法 采集、标记并用电子游标卡尺测量POF组与正常对 照组左、右手各手指指长，比较两组间指长比情况。结果 POF组月经初潮年龄迟于对照组（t=4.597，P<0.05）。 两组间左右手指长比分布趋势呈2D∶3D<2D∶4D<3D∶4D<2D∶5D<4D∶5D<3D∶5D，指长比比较差异无统计学意义（ P>0.05）。POF组和对照组左右手2D∶4D分布构成差异无统计学意义（P>0.05）。POF组继发闭经者右手4D∶5D指 长比大于原发性闭经者（t=-2.073，P<0.05），其余各指长比差异无统计学意义（P>0.05）。结论 月经初潮年龄 推迟可能是POF患者早期筛查参考指标之一，右手4D∶5D可能与继发性闭经相关。
Abstract:
Objective To investigate the relationship between the digit ratio and premature ovarian failure （POF） patients. Methods Digit ratios of left and right hands were measured with electronic calipers，then the situation between the two groups was compared. Results Premature ovarian failure group age of menarche was significantly later than the control group，the difference was statistically significant（t=4.597，P<0.05）. The two groups had the same distribution trends: 2D∶3D<2D∶4D<3D∶4D<2D∶5D<4D∶5D<3D∶5D. There was no significant significance on digit ratio between the two groups（P>0.05）. Premature ovarian failure group and the control group 2D∶4D distribution constituent ratio had no significant difference（P>0.05）. Premature ovarian failure group right 4D∶5D digit ratio secondary amenorrhea was significantly higher than primary amenorrhea （t=-2.073，P<0.05），and the rest of the digit ratio was no significant difference（P>0.05）. Conclusion Delayed age at menarche early screening may be one of the reference index in patients with premature ovarian failure. 4D∶5D of right hand may be an indicator of secondary amenorrhea.

参考文献/References:

[1] Manning JT，Bundred P. The ratio of 2nd to 4th digit length：a new predictor of disease predisposition[J]. Med Hypoth，2000，54（5）：855-857.
[2] Manning JT，“Digit Ratio”[M]. Rutgers University Press，2002.
[3] 陆宏，霍正浩，师志云，等. 宁夏回族和汉族群体指长比的研究[J]. 解剖学报，2008，39（2）:267-271．
[4] 赵君利，李彩艳，等. 指长比与PCOS 及其并发症的相关性研究[J].宁夏医科大学学报，2012,34（5）:438．
[5] Manning JT，Scutt D，Wilson J，et al. The ratio of 2nd to 4th digit length: a predictor of sperm numbers and concentrations of testosterone，luteinizing hormone and oestrogen[J]. Hum Reprod，1998，13（11）:3000-3004．
[6] Lutchmaya S，Baron-Cohen S，Raggatt P，et al. 2nd to 4th digit ratios，fetal testosterone and estradiol[J]. Early Hum Dev，2004，77（1）:23-28.
[7] Puts DA，McDaniel MA，Jordan CL，et al. Spatial ability and prenatal androgens: Meta-analyses of congenital adrenal hyperplasia and digit ratio（2D∶4D） studies[J]. Arch Sex Behav，2008，37（1）:100-111.
[8] Lu H，Huo Z，Liu Y，et al. Correlations between digit ratio and infertility in Chinese men[J]. Early Hum Dev，2012，88（11）:865-869.
[9] 马丽丽. 宁夏人群卵巢早衰患者与GDF-9/BMP-15基因的遗传学研究[D]. 宁夏医科大学，2013.
[10] Manning JT，Henzi P，Venkatramana P，et al. Second to fourth digit ratio: ethnic differences and family size in English，Indian and South African populations[J]. Ann Hum Biol，2003，30（5）:579-588.

相似文献/References:

[1]闫 蓉,贺晓慧.中医药同步调理精卵功能治疗不孕不育的疗效分析[J].宁夏医科大学学报,2010,(01):144.
[2]赵君利,刘 丽,刘 蔚,等.女性指长比与卵巢功能[J].宁夏医科大学学报,2012,(09):864.
　ZHAO Jun-li,LIU Li,LIU Wei,et al.The Association between Digit Ratios and Ovarian Function[J].Ningxia Medical University,2012,(11):864.
[3]赵君利,刘 丽,刘 蔚,等.女性指长比与卵巢功能[J].宁夏医科大学学报,2012,(09):864.
　ZHAO Jun-li,LIU Li,LIU Wei,et al.The Association between Digit Ratios and Ovarian Function[J].Ningxia Medical University,2012,(11):864.
[4]袁莹莹,赵君利,刘 丽,等.体外受精助孕患者染色体核型特点分析[J].宁夏医科大学学报,2012,(08):779.
　YUAN Ying-ying,ZHAO Jun-li,LIU Li,et al.Clinical Analysis of Chromosomal Abnormalities among Patients Undergoing in Vitro Fertilization-embryo Transfer[J].Ningxia Medical University,2012,(11):779.
[5]赵君利,李彩艳,刘蔚,等.指长比与PCOS及其并发症的相关性研究[J].宁夏医科大学学报,2012,(05):438.
　ZHAO Jun-li,LI Cai-yan,LIU Wei,et al.The Association of Digit Ratios and PCOS and its Complications in Ningxia[J].Ningxia Medical University,2012,(11):438.
[6]刘 丽,赵君利、.辅助生殖技术中的心理问题及其干预研究现状[J].宁夏医科大学学报,2012,(01):96.
[7]马永静,李梅兰.腹宫腔镜联合在女性盆腔及宫腔病变不孕症诊治中的应用[J].宁夏医科大学学报,2012,(01):73.
[8]张淑雅,陈 昕,桑旭东,等.胶原盘状结构域受体2基因缺失对小鼠卵巢功能的影响[J].宁夏医科大学学报,2013,(12):1333.
　ZHANG Shuya,CHEN Xin,SANG Xudong,et al.The Effect of Discoidin Domain Receptor 2 Deficiency on Ovarian Function in Mice[J].Ningxia Medical University,2013,(11):1333.
[9]刘 丽,赵君利,袁莹莹.不孕症患者人格特点与指长比的相关性分析[J].宁夏医科大学学报,2013,(12):1318.
　LIU Li,ZHAO Junli,YUAN Yingying.Relationship between Personality Traits and Finger Length Ratios in Infertile Patients[J].Ningxia Medical University,2013,(11):1318.
[10]单 菲,曹 征,槐中美.子宫内膜异位性不孕症患者腹腔镜手术疗效及对血清相关指标的影响[J].宁夏医科大学学报,2013,(07):823.
[11]哈春芳,窦海丽,曹 丹,等.ADM低表达与月经过多及原因不明性不孕的关系[J].宁夏医科大学学报,2013,(04):365.
　HA Chun-fang,DOU Hai-li,CAO Dan,et al.The Relationship of Low ADM Expression with Menorrhagia and Infertility[J].Ningxia Medical University,2013,(11):365.

备注/Memo

备注/Memo:
收稿日期：2017-02-12
基金项目：国家自然科学基金（81060051，31460272）；宁夏自然科学基金（NZ11267）
作者简介：程方（1984-），女，山西人，从事生殖内分泌研究方向。
通信作者：赵君利。E-mail：zhaojunli6812@163.com
更新日期/Last Update: 1900-01-01