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[1]吴嘉荔,冀晓静,李文峰,等.20%脂肪乳剂对急性有机磷农药中毒患者血清炎症因子的影响[J].宁夏医科大学学报,2017,(11):1258-1262.[doi:10.16050/j.cnki.issn1674-6309.2017.11.005]
 WU Jiali,JI Xiaojing,LI Wenfeng,et al.Effect of 20% Fat Emulsion on Inflammatory Factors in Patients with Acute Organophosphorus Pesticide Poisoning[J].Ningxia Medical University,2017,(11):1258-1262.[doi:10.16050/j.cnki.issn1674-6309.2017.11.005]
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20%脂肪乳剂对急性有机磷农药中毒患者血清炎症因子的影响(PDF)
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《宁夏医科大学学报》[ISSN:1005-8486/CN:64-1029/R]

卷:
期数:
2017年11期
页码:
1258-1262
栏目:
论著
出版日期:
2017-11-30

文章信息/Info

Title:
Effect of 20% Fat Emulsion on Inflammatory Factors in Patients with Acute Organophosphorus Pesticide Poisoning
作者:
吴嘉荔1冀晓静2李文峰1杨立山1
1. 宁夏医科大学总医院急诊科,银川 750004; 2.解放军第五医院检验科,银川 750004
Author(s):
WU Jiali1JI Xiaojing2LI Wenfeng1YANG Lishan1
1. General Hospital of Ningxia Medical University,Yinchuan 750004; 2. The Fifth Hospital of Chinese People`s Liberation Army,Yinchuan 750004
关键词:
有机磷农药中毒20%脂肪乳剂炎症因子炎性反应
Keywords:
organophosphorus pesticide poisoning 20% fat emulsioninflammatory factor inflammatory response
分类号:
R595
DOI:
10.16050/j.cnki.issn1674-6309.2017.11.005
文献标志码:
A
摘要:
目的 探讨20%脂肪乳剂对急性有机磷农药中毒(AOPP)患者血清炎症因子的影响及其临床意义。方法 选择 2016年2月1日-2016年12月3日收治的重度AOPP患者80例,随机分为实验组和对照组。实验组在常规治疗基础上, 在入院后行血液灌流前给予20%脂肪乳剂治疗,对照组仅给予常规治疗方案,分别对两组患者在治疗前及治疗后第 1、3、5天行血清C反应蛋白(CRP)、肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)检测。结果 治疗后实验 组死亡1例,对照组死亡2例。治疗前两组患者CRP、IL-6及TNF-α水平差异无统计学意义(P>0.05)。两组患者治 疗后各时间点CRP均高于治疗前(P<0.01)。治疗后第3天,实验组CRP水平低于对照组(P<0.01)。实验组及对照 组TNF-α均在治疗后第1天增高至峰值,且对照组高于治疗前(P<0.01),第3、5天两组TNF-α均低于治疗前 (P<0.01)。治疗后第1天和第3天实验组TNF-α低于对照组(P<0.05或<0.01)。实验组在治疗后第3、5天IL-6低 于治疗前(P均<0.01);对照组在治疗后第1天、第3天IL-6水平均高于治疗前(P<0.05或<0.01),至第5天低于 治疗前(P<0.01)。治疗后第1、3、5天实验组IL-6均低于对照组(P均<0.01)。结论 20%脂肪乳剂在一定程度上 可减少AOPP患者炎症因子的产生,减轻AOPP患者的炎性反应。
Abstract:
Objective To investigate the effect and clinical significance of 20% fat emulsion on inflammatory factors in patients with acute organophosphorus pesticide poisoning(AOPP). Methods It’s a prospective randomized controlled study,80 patients with severe AOPP were included, randomly divided into experimental group and control group. The treatment of 20% fat emulsion was given to the experimental group before blood perfusion based on the routine treatment,the control group was only given the routine treatment. The c-reactive protein(CRP),tumor necrosis factor- α(TNF-α) and interleukin-6 (IL-6) were measured for the two groups` patients respectively at the days of before treatment and the 1st,3rd,5th days after treatment.Through the statistical analysis,the differences of CRP,TNF-α,IL-6 of the two groups were compared. Results There were 40 cases in each group. The sex,age,oral organophosphorus pesticide type,oral dose and poisoning time of the two groups had no significant differences. After treatment,there was 1 case died in experimental group and 2 cases died in the control group. The CRP value of the experimental group and the control group were increased at the first day,and decreased at the 3rd day,the value of each time had significant difference with the prior treatment (P<0.01). The value of CRP had no significant difference between the two groups before treatment,but after 5 days’ treatment(P>0.05),the difference between the two groups was statistically significant (P<0.05) . On the third day after treatment,the CRP value in the experimental group was lower than the control group,the difference between the two groups was statistically significant(P<0.05). The levels of TNF-α in both groups began to increase on the first day,and decreased on the 3rd day after treatment gradually. After treatment,on the 3rd,5th days of the experimental and each time of the control group,the TNF-α value was significantly different from the prior treatment( P<0.01).The values of TNF-α was no significant difference in between the two groups before and after treatment(P>0.05),the values of TNF-α was lower in the experimental group than the control group on the 1st and 3rd day after treatment,the difference between the two groups was statistically significant (P<0.05). The IL-6 value of experimental group was no significant difference with the day that before treatment at the 1st day(P>0.05),but lower than the day that before treatment at the 3td and 5th day(P<0.01). The IL-6 value of control group was higher than the day that before treatment at the 1st and 3rd day(P<0.05 or P<0.01),lower at the 5th day. The values of IL-6 had no significant difference between the two groups that before treatment (P>0.05),but at the 1st,3rd and 5th days after treatment,the values of IL-6 in experimental group was lower than control group,the difference between the two groups was statistically significant (P<0.05). Conclusion The treatment of 20% fat emulsion can reduce the production of inflammatory factors and the inflammatory response in a certain extent for the patients with AOPP.

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备注/Memo

备注/Memo:
收稿日期:2017-04-10
基金项目:宁夏医科大学校级科研项目(XM2015064)
作者简介:吴嘉荔(1983-),男,在职硕士研究生,主治医师,主要从事急诊医学相关研究工作。
通信作者:杨立山,男,宁夏人,主任医师,教授,硕士研究生导师,从事急诊医学医疗、教学及科研工作。 E-mail:nyfyyls@126.com
更新日期/Last Update: 1900-01-01