|本期目录/Table of Contents|

[1]马万瑞,丁 莉,王志忠,等.社区老年人轻度认知功能障碍危险因素的病例对照研究[J].宁夏医科大学学报,2013,(10):1103-1105.
 MA Wanrui,DING Li,WANG Zhizhong,et al.A Case-control Study of Risk Factors of Cognitive Impairment in Community Elderly[J].Ningxia Medical University,2013,(10):1103-1105.
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《宁夏医科大学学报》[ISSN:1005-8486/CN:64-1029/R]

卷:
期数:
2013年10期
页码:
1103-1105
栏目:
论著
出版日期:
2013-10-20

文章信息/Info

Title:
A Case-control Study of Risk Factors of Cognitive Impairment in Community Elderly
作者:
马万瑞1 丁 莉2 王志忠2 刘 兰2 李 涛2 张金玲3
1.宁夏医科大学总医院综合科,银川 750004; 2.宁夏医科大学公共卫生学院流行病与卫生统计学系, 银川 750004; 3.宁夏医科大学心脑血管病医院内分泌科,银川 750002
Author(s):
MA Wanrui1 DING Li2 WANG Zhizhong2 LIU Lan2 LI Tao2 ZHANG Jinling3
1.The General Hospital of Ningxia Med. Univ., Yinchuan 750004; 2.School of Public Health, Ningxia Med. Univ., Yinchuan 750004; 3.Cardio Cerebrovascular Disease Hospital of Ningxia Med. Univ., Yinchuan 750002
关键词:
轻度认知功能障碍危险因素病例对照研究回族
Keywords:
cognitive impairment risk factors case-control study Hui nationality
分类号:
R749.1
DOI:
-
文献标志码:
A
摘要:
目的分析影响回、汉族社区老年人轻度认知功能障碍的可能危险因素,为开展轻度认知功能障碍的社区干预提供参考。方法以社区现场调查诊断的124例轻度认知功能障碍患者为病例组,以性别、年龄、民族为匹配条件,采用1∶1匹配的病例对照设计,分析比较两组受试对象的血清总睾酮、雌二醇、黄体生成素、卵泡刺激素、性激素结合球蛋白以及生化指标的水平,条件Logistic回归模型用于多因素分析。结果轻度认知功能障碍组血清TC、LDL水平显著高于对照组,差异有统计学意义(P<0.05)。条件Logistic回归最终进入方程的因素有总胆固醇(OR=0.71,95%CI:0.54~0.95)。结论在控制了性别、年龄和民族等因素的影响后,血清中性激素水平与老年人轻度认知功能障碍无关联。
Abstract:
Objective To analyze the possible risk factors that affect the elderly cognitive impairment in Hui, Han community and to provide reference for carrying out the community-based interventions of cognitive impairment. Methods 124 cases with cognitive function disorders were selected from community site investigation as cases while 124 normal subjects were selected as controls. Matching factors included gender, age, ethnicity and 1:1matched case-control design were used to compare the levels of serum total testosterone, estradiol, luteinizing hormone, follicle-stimulating hormone, sex hormone-binding globulin, and biochemical indicators between cases and controls. Conditional logistic regression model were adopted for multivariate analysis. Results The levels of serum TC and LDL in cases were significantly higher than those in controls(P<0.05). Serum levels of total testosterone, estradiol, luteinizing hormone, follicle-stimulating hormone, sex hormone-binding globulin levels showed no significant difference between cases and controls. The total cholesterol were in the equation after multivariate conditional logistic regression(OR=0.71, 95% CI=0.71, 95% .54~0.95). Conclusion After controlling the factors such as gender, age and ethnic, the serum sex hormone levels had no significant correlation with cognitive dysfunction in the elderly.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2013-02-26 基金项目:宁夏自然科学基金(NZ1082) 作者简介:马万瑞(1984-),女,山西人,住院医师。 通信作者:王志忠。E-mail: wzhzh_lion@126.com
更新日期/Last Update: 2013-10-20