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[1]张桂香,刘新兰,赵艳娇.乳腺癌骨转移临床特点及其预后影响因素的研究[J].宁夏医科大学学报,2013,(09):987-990.
 ZHANG Guixiang,LIU Xinlan,ZHAO Yanjiao.Clinical Features and Prognostic Factors in Cases with Breast Cancer Metastasis to Bone[J].Ningxia Medical University,2013,(09):987-990.
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乳腺癌骨转移临床特点及其预后影响因素的研究(PDF)
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《宁夏医科大学学报》[ISSN:1005-8486/CN:64-1029/R]

卷:
期数:
2013年09期
页码:
987-990
栏目:
论著
出版日期:
2013-09-30

文章信息/Info

Title:
Clinical Features and Prognostic Factors in Cases with Breast Cancer Metastasis to Bone
作者:
张桂香1 刘新兰2 赵艳娇3
3.宁夏医科大学临床医学院,银川 750004
Author(s):
ZHANG Guixiang1 LIU Xinlan2 ZHAO Yanjiao3
1.Ningxia People's Hospital, Yinchuan 750021; 2.Cancer Hospital, Ningxia Med. Univ., Yinchuan 750004; 3.School of Clinical Medicine, Ningxia Med. Univ., Yinchuan 750004
关键词:
乳腺癌 骨转移 临床病理特征 生存分析 预后因素
Keywords:
breast cancer bone metastasis clinical pathology characteristics survival analysis prognosis
分类号:
R737.9
DOI:
-
文献标志码:
A
摘要:
目的 分析乳腺癌骨转移患者的临床及病理特点,探讨乳腺癌骨转移的规律及预后影响因素。方法 对宁夏医科大学总医院2002年1月-2011年1月确诊为乳腺癌骨转移的病例资料进行回顾性分析,通过电话或复诊进行随访。结果 150例乳腺癌骨转移患者骨转移以多发病灶起病为主,其好发部位依次为脊柱、胸部、骨盆、肢体、颅骨,转移率分别为75.3%、74.0%、56.0%、46.7%、28.7%,不同转移部位之间的差异有统计学意义(P<0.01)。Kaplan-Meier单因素分析结果显示:年龄、月经状态、淋巴结转移数目、临床分期、CerbB-2状态、内分泌治疗与否、是否合并内脏转移、骨转移部位数是影响乳腺癌骨转移患者总生存的因素。Cox多因素回归结果分析显示,内分泌治疗与否、淋巴结转移数目、是否合并内脏转移、骨转移部位数和CerbB-2状态与乳腺癌骨转移的发生有关。结论 乳腺癌骨转移易发生于中老年人,以35~60岁年龄段为主。淋巴结转移数目多、未经内分泌治疗、合并内脏转移、初发时骨转移病灶数目多及CerbB-2表达阳性是乳腺癌骨转移的危险因素。
Abstract:
Objective To analyze the clinical and pathological features of bone metastasis from breast cancer and to explore regulation and prognostic factors in cases with breast cancer metastasis to bone. Method Information in 150 cases with breast cancer metastasis to bone was selected Via calling, re-examination and interviewing in the General Hospital of Ningxia Medical University from Jan. 2002 to Jan. 2011. Result Totally 150 cases bone metastasis occured mainly in multiple focuses and metastasis parts in sequences were spine, chest, pelvis, limbs and skull. Metastasis rate was 75.3%, 74.0%, 56.0%, 46.7% and 28.7% respectively and there was significant difference between different metastasis parts(P<0.01). Single factor analysis of Kaplan-Meier showed that the age, menstrual status, lymph node metastasis quantity, stage, endocrine treatment,, combination of visceral metastasis, CerbB-2 and parts of bone metastasis were general factors of bone metastasis from breast cancer.Multiple causes Cox regression analysis showed that endocrine treatment, lymph node metastasis quantity, combination of visceral metastasis, CerbB-2 and parts of bone metastasis were independent factors of prognosis. Conclusions 1.Bone metastasis from breast cancer is prone to the aged, mainly focus among 35 to 60. Parts of metastasis in sequences are spine, chest, pelvis, limbs and skull.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2012-12-14 作者简介:张桂香(1986-),女,硕士。 通信作者:刘新兰,教授,硕士生导师,从事乳腺癌临床及基础研究。E-mail:liuxinlan@csco.org.cn
更新日期/Last Update: 2013-09-20