|本期目录/Table of Contents|

[1]徐冀东,姜 宁,王国增,等.肾结石患者输尿管软镜碎石术后早期尿NGAL与Cys C的变化[J].宁夏医科大学学报,2013,(07):763-765,769.
 XU Ji-dong,JIANG Ning,WANG Guo-zeng,et al.Early Changes of uNGAL and uCys C in Renal Calculi Cases with the Flexible Ureteroscope and Laser Lithotripsy[J].Ningxia Medical University,2013,(07):763-765,769.
点击复制

肾结石患者输尿管软镜碎石术后早期尿NGAL与Cys C的变化(PDF)
分享到:

《宁夏医科大学学报》[ISSN:1005-8486/CN:64-1029/R]

卷:
期数:
2013年07期
页码:
763-765,769
栏目:
论著
出版日期:
2013-07-20

文章信息/Info

Title:
Early Changes of uNGAL and uCys C in Renal Calculi Cases with the Flexible Ureteroscope and Laser Lithotripsy
作者:
徐冀东1 姜 宁2 王国增2 贺 伟2 章 璟2 郑景存1
1.宁夏医科大学,银川 750004; 2.上海市浦东新区公利医院泌尿外科,上海 200135
Author(s):
XU Ji-dong1 JIANG Ning2 WANG Guo-zeng2 HE Wei2 ZHANG Jing2 ZHENG Jing-cun1
1.Ningxia Medical University, Yinchuan 750004; 2.Shanghai Pudong New Area Gongli Hospital, Shanghai 200135
关键词:
中性粒细胞明胶酶相关载脂蛋白 半胱氨酸蛋白酶抑制剂 C 肾结石 输尿管软镜 早期肾损伤
Keywords:
extracorpored shock wave lithotripsy cystatin C kidney stones flexible ureteroscope early renal injury
分类号:
R691.4
DOI:
-
文献标志码:
A
摘要:
目的 通过检测肾结石患者输尿管软镜钬激光碎石术(后称输尿管软镜碎石术)后不同时间点尿液NGAL(neutrophil gelatinase-associated lipocalin,uNGAL)与半胱氨酸蛋白酶抑制剂 C(cystatin C,uCys C)的变化情况,探讨其判断肾结石输尿管软镜碎石术后早期肾功能(肾小管和肾小球)变化的意义。方法 筛选肾结石患者30例,分别收集其输尿管软镜碎石术前及术后2、6、12、24h和1周的尿液及血清标本,检测不同时点患者uNGAL、uCys C浓度与血清肌酐(serum creatinine,Scr)的浓度。结果 uNGAL与uCys C在术后各时间点的浓度较术前均有明显增高,uNGAL在术后2h开始升高,在12h达到高峰,24h后下降(P<0.05); 1周时基本恢复到术前水平(P>0.05)。uCys C在术后6h开始升高,在12h达到高峰,24h有所下降,1周时仍高于术前水平(P<0.05)。术后各时间点Scr无明显变化(P>0.05)。结论 检测uNGAL与uCys C浓度可以作为评价肾结石输尿管软镜术后早期肾损伤的有效手段。
Abstract:
Objective By detecting the urinary NGAL(uNGAL)and urinary Cystatin C(uCys C)of the patients after flexible ureteroscope laser lithotripsy at different times to determine the changes of early postoperative renal function(tubular and glomerular function)in renal calculi cases with flexible ureteroscope and laser lithotripsy. Methods Blood and urine samples at preoperative, and postoperative 2,6,12,24h and 1w were collected in 30 patients with kidney stones. uNGAL,uCys C and serum creatinine(Scr)concentration were detected. Results There was no significant changes in Scr between different postoperative time(P>0.05). The expression of uNGAL and uCys C showed significantly increased in postoperative time point than those in the preoperative time point.Urinary NGAL began to increase at postoperative 2h, peaked at postoperative 12h, declined after postoperative 24h, basically returned to preoperative levels at postoperative 1week. uCys C began to increase at postoperative 6h, peaked at postoperative 12h, declined after postoperative 24h, was still higher than preoperative levels at postoperative 1w. Conclusion Detecting uNGAL and uCys C concentration is a noninvasive and effective means of detection as evaluation of flexible ureteroscope laser lithotripsy early postoperative kidney injury.

参考文献/References:

[1] 叶章群.泌尿系结石研究现状与展望[J].中华实验外科杂志,2005,22(3):261-262.
[2] 孙颖浩.泌尿系结石微创治疗的若干问题[J].中国微创外科杂志,2011,1l(1): 12.
[3] 赵庆利,李博,李青.输尿管镜/软镜手术常见并发症的防治[J].山东医药,2010,50(39):109.
[4] Jaya Mishra,Catherine Dent,et al.Neutrophil gelatinase-associated lipocalin(NGAL)as a biomarker for acute renal injury after cardiac surgery [J].Lancet,2005(365):1231-1238.
[5] Bolignano D,Donato V,Coppolino G,et al.Neutrophil gelatinase-associated lipocalin(NGAL)as a marker of kidney damage [J].Am J Kidney Dis,2008,52(3):595-605.
[6] Donadio C,Luehesi A.Serum cystatin as a marker of glomerular filtration rate [J].Am J Kidney Dis,2001,37(2):448-451.
[7] 张石珠,杨敬伟,陈宪典,等.急性肾损伤患者血清胱抑素-C及尿NGAL水平的变化及其临床意义 [J].现代生物医学进展,2012,12(15):2943-2945.
[8] Devarajan P.Emerging biomarkers of acute kidney injury [J].Contrib Nephrol,2007,156:203-212.
[9] Laterza OF,Price CP,Scott MG.Cystatin C:an imp roved estimator of glomerular filtration rate[J].Clinical Chemistry,2002,48(12):699-707.
[10] Risch L,Huber AR.Assessing the diagnostic accuracy of cystatin C as a marker of impaired glomerular filtration rate [J].Am J Kidney Dis,2002,39:661-662.
[11] 王海滨,熊瑜琳,于勇,等.胱抑素C 在重度烧伤患者早期肾损伤中的临床意义[J].临床军医杂志,2009,37(5):815-817.
[12] 杜立树,平龙玉,涂林,等.尿微量白蛋白与血清胱抑素C 联合检测对早期肾功能损伤的临床探讨[J].成都医学院学报,2009,4(2):107-109.

相似文献/References:

[1]郄雅萍,张楠,强建新,等.血清NGAL与慢性肾病患者冠状动脉斑块钙化相关性研究[J].宁夏医科大学学报,2017,(07):760.[doi:10.16050/j.cnki.issn1674-6309.2017.07.006]
 XI Yaping,ZHANG Nan,QIANG Jianxin,et al.The Association between Serum Neutrophil Gelatinase-associated Lipocalin and Coronary Atherosclerosis Calcification in Patients with Chronic Kidney Diseases[J].Ningxia Medical University,2017,(07):760.[doi:10.16050/j.cnki.issn1674-6309.2017.07.006]
[2]赵贵成,张韬,沈军,等.输尿管软镜联合钬激光治疗上尿路结石109例疗效分析[J].宁夏医科大学学报,2016,(01):88.[doi:10.16050/j.cnki.issn1674-6309.2016.01.025]
[3]郭军,丁瑜,李晓燕.低能量、低剂量体外震波碎石术治疗多囊肾合并肾结石[J].宁夏医科大学学报,2014,(10):1161.
[4]才春东,姜 宁,王国增,等.枸橼酸钾对大鼠肾草酸钙结石骨桥蛋白表达的影响[J].宁夏医科大学学报,2010,(02):176.
 CAI Chun-dong,JIANG Ning,WANG Guo-zeng,et al.Effects of Citrate on Osteopontin Expression of UrinaryOxalate Calcium StoneFormation in Rats[J].Ningxia Medical University,2010,(07):176.

备注/Memo

备注/Memo:
收稿日期:2013-03-24 基金项目:上海市卫生局科技项目基金(20124310); 上海市浦东新区卫生局科技项目基金(PW2012A-8) 作者简介:徐冀东,男,内蒙古人,在读硕士研究生,从事泌尿外科临床工作。 通信作者:姜宁,主任医师,研究方向:泌尿系结石。E-mail:402424473@qq.com
更新日期/Last Update: 2013-07-20