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[1]侯西倩,竺 红.MMP-9、BAFF在原发性干燥综合征患者唇腺组织中 表达的相关研究[J].宁夏医科大学学报,2013,(04):424-4287.
 HOU Xi-qian,ZHU Hong.Expression of MMP-9 and BAFF in the Labial Gland of Patients with Primary Sjgren's Syndrome[J].Ningxia Medical University,2013,(04):424-4287.
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MMP-9、BAFF在原发性干燥综合征患者唇腺组织中 表达的相关研究(PDF)
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《宁夏医科大学学报》[ISSN:1005-8486/CN:64-1029/R]

卷:
期数:
2013年04期
页码:
424-4287
栏目:
论著
出版日期:
2013-04-20

文章信息/Info

Title:
Expression of MMP-9 and BAFF in the Labial Gland of Patients with Primary Sjögren's Syndrome
作者:
侯西倩1 竺 红2
1.宁夏医科大学,银川 750004; 2.宁夏医科大学总医院风湿科,银川 750004
Author(s):
HOU Xi-qian1 ZHU Hong2
1.Ningxia Medical University,Yinchuan 750004; 2.The General Hospital of Ningxia Medical University, Yinchuan 750004
关键词:
干燥综合征 唇腺疾病 免疫组织化学 基质金属蛋白酶-9 B细胞激活因子
Keywords:
sjögren's syndrome salivary gland diseases immunohistochemistry matrix metalloproteinase-9 B cell activating factor of the tumor necrosis factor family
分类号:
R442.8
DOI:
-
文献标志码:
A
摘要:
目的 探讨基质金属蛋白酶-9(matrix metalloproteinase-9,MMP-9)、B细胞激活因子(B cell activating factor of the tumor necrosis factor family,BAFF)在原发性干燥综合征(PSS)发病过程中的作用和意义。方法 采用免疫组化SP法检测50例PSS患者及30例正常对照组唇腺组织中MMP-9、BAFF的表达情况。结果 50例PSS患者唇腺组织中MMP-9均阳性高表达,其表达的面积(14382.38±657.39 )μm2、累积光密度(2705.46±868.76)均高于正常对照组(8445.10±361.84)μm2、(1114.26±570.82),且随着淋巴细胞浸润等级的增加,MMP-9表达增强,差异有统计学意义(P<0.05); 50例PSS组患者唇腺组织中BAFF均阳性表达,其表达的面积(13586.72±1569.45)μm2、累积光密度(2073.57±850.73)均高于正常对照组(7116.83±338.19)μm2、(850.73±120.31),且随着淋巴细胞浸润等级的增加,BAFF表达增强(P<0.05); PSS组患者唇腺组织中MMP-9与BAFF的表达呈正相关(P<0.05)。结论 MMP-9、BAFF的异常表达与原发性干燥综合征患者唇腺组织的破坏有关,二者参与了PSS的发病过程。
Abstract:
Objective To investigate the expression of matrix metalloproteinase-9(MMP-9)and B cell activating factor of the tumor necrosis factor family(BAFF)in the labial gland of patients with Primary Sjögren's Syndrome(PSS)and to analyse their roles in the pathogenesis of PSS. Methods The expression of MMP-9and BAFF were detected by the Immunohistochemical method. The labial gland were obtained from 50 patients with PSS and 30 healthy controls. Results The MMP-9 protein and BAFF protein were both over-expressed in the labial gland of patients with PSS. The mean over-expression level(14382.38±657.39)μm2, integrated optical density(2705.46±868.76)of MMP-9 and the mean over-expression level(13586.72±1569.45)μm2, integrated optical density(2073.57±850.73)of BAFF in PPS patients' tissues were all significantly higher than those in normal salivary tissues(8445.10±361.84, 1114.26±570.82; 7116.83±338.19, 850.73±120.31),P<0.05. There was a positive correlation between the expression of MMP-9and BAFF(P<0.05).Conclusion The over-expression of MMP-9and BAFF and the interaction between them in the labial gland of patients with PSS may play an important role in the pathogeny of PSS.

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备注/Memo

备注/Memo:
收稿日期:2012-11-18 基金项目:宁夏医科大学重点孵育项目(2010年) 作者简介:侯西倩(1986-),女,山东人,在读硕士研究生,主要从事风湿病研究。 通信作者:竺红(1970-),女,副教授,硕士研究生导师。E-mail:nxzhuh@126.com
更新日期/Last Update: 2013-04-20