|本期目录/Table of Contents|

[1]王 露,金梅花,徐清斌,等.原发性高血压患者血管紧张素Ⅱ-2型受体基因C3123A 多态性及其相关因素的研究[J].宁夏医科大学学报,2013,(04):382-385.
 WANG Lu,JIN Mei-hua,XU Qing-bin,et al.Relationship between C3123A Polymorphism of AngiogenesisⅡ Type 2 Receptor Gene and Essential Hypertension of Hans in Ningxia[J].Ningxia Medical University,2013,(04):382-385.
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原发性高血压患者血管紧张素Ⅱ-2型受体基因C3123A 多态性及其相关因素的研究(PDF)
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《宁夏医科大学学报》[ISSN:1005-8486/CN:64-1029/R]

卷:
期数:
2013年04期
页码:
382-385
栏目:
论著
出版日期:
2013-04-20

文章信息/Info

Title:
Relationship between C3123A Polymorphism of AngiogenesisⅡ Type 2 Receptor Gene and Essential Hypertension of Hans in Ningxia
作者:
王 露1 金梅花2 徐清斌2 马 萍2
1.宁夏医科大学,银川 750004; 2.宁夏医科大学总医院心内科,银川 750004
Author(s):
WANG Lu1 JIN Mei-hua2 XU Qing-bin2 MA Ping2
1.Ningxia Medical University,Yinchuan 750004; 2.Department of Cardiology, the General Hospital of Ningxia Medical University,Yinchuan 750004
关键词:
原发性高血压 血管紧张素Ⅱ-2型受体 基因多态性 宁夏 汉族
Keywords:
essential hypertension angiogenesisⅡ type 2 receptor gene polymorphism Ningxia Han nationality
分类号:
R544.1
DOI:
-
文献标志码:
A
摘要:
目的 研究血管紧张素Ⅱ2型受体(angiogenesisⅡ type2,AT2R)基因C3123A多态性与宁夏地区汉族人群原发性高血压(essential hypertension,EH)的关系。方法 选取宁夏地区汉族原发性高血压患者137例(EH组,男71例,女66例)和正常血压者149例(NT组,男63例,女86例), 应用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)技术检测AT2R基因多态性。结果 男、女EH组AT2R基因C3123A位点各基因型频率、等位基因频率与NT组相比差异均无统计学意义(P>0.05); 二元逐步Logistic回归显示女EH组中BMI、肌酐、空腹血糖为危险因素,男EH组中BMI为危险因素。结论 AT2R基因多态性与宁夏汉族原发性高血压患者发病无明显相关。
Abstract:
Objective To investigate the association between the polymorphism of angiogenesisⅡ type 2 receptor(AT2R)gene C3123A and essential hypertension(EH)of Hans in Ningxia. Methods The study was performed in 137 patients with essential hypertension and 149 healthy controls. Blood samples of these groups were collected and DNA was extracted. AT2R gene polymorphism was detected by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP). Results In male and female subgroup:The frequencise of each genotypes and allelics showed no significant difference between EH group and NT group(P>0.05).Binary stepwise logistic regression analysis showed that body mass index(BMI),creatinine(Cr)and glueose(GLU)were independent risk factors for essential hyper- tension in famale subgroup,body mass index(BMI)also was risk factor for EH in male's. Conclusion No significant association was found between the C3123A polymorphism of AT2R gene and essential hypertension in Hans of Ningxia.

参考文献/References:

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[2] 首云锋,陈明.血管紧张素受体AT2及AT4研究进展[J].心血管病学进展,2010,31(1):58-61.
[3] 张利荣,和姬苓.血管紧张素-Ⅱ2型受体基因多态性与高血压心脑血管病的研究进展[J].西部医学,2010,22(1):148-150.
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[5] Miyaki K,Hara A,Araki J,et al.C3123A polymorphism of the angiotensin II type 2 receptor gene and salt sensitivity in healthy Japanese men[J].Journal of Human Hypertension,2006, 20(6):467-469.
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备注/Memo

备注/Memo:
收稿日期:2012-10-30 基金项目:宁夏自然科学基金(NZ10134) 作者简介:王露,女,在读硕士研究生。 通信作者:马萍,女,副主任医师,硕士研究生导师,从事心血管内科临床工作。E-mail:xu-qb@163.com
更新日期/Last Update: 2013-04-20