|本期目录/Table of Contents|

[1]赵艳姣,刘新兰,马志兰.VEGF-C、VEGFR-3和LYVE-1在胃癌中的表达及其临床意义[J].宁夏医科大学学报,2013,(04):378-381.
 ZHAO Yan-jiao,LIU Xin-lan,MA Zhi-lan.Expression and Clinical Significance of VEGF-C, VEGFR-3 and LYVE-1 in Gastric Cancer[J].Ningxia Medical University,2013,(04):378-381.
点击复制

VEGF-C、VEGFR-3和LYVE-1在胃癌中的表达及其临床意义(PDF)
分享到:

《宁夏医科大学学报》[ISSN:1005-8486/CN:64-1029/R]

卷:
期数:
2013年04期
页码:
378-381
栏目:
论著
出版日期:
2013-04-20

文章信息/Info

Title:
Expression and Clinical Significance of VEGF-C, VEGFR-3 and LYVE-1 in Gastric Cancer
作者:
赵艳姣1 刘新兰2 马志兰1
1.宁夏医科大学,银川 750004; 2.宁夏医科大学总医院肿瘤医院肿瘤内科,银川 750004
Author(s):
ZHAO Yan-jiao1 LIU Xin-lan2 MA Zhi-lan1
1.Ningxia Medical University,Yinchuan 750004; 2.Tumor Hospital of General Hospital, Ningxia Medical Hospital, Yinchuan 750004
关键词:
胃癌 血管内皮生长因子C 血管内皮细胞生长因子受体-3 淋巴管透明质酸受体-1 免疫组化
Keywords:
gastric carcinoma VEGF-C VEGFR-3 LYVE-1 IHC
分类号:
R735.2
DOI:
-
文献标志码:
A
摘要:
目的 探讨胃癌组织中血管内皮生长因子C(VEGF-C)、血管内皮细胞生长因子受体-3(VEGFR-3)及淋巴管透明质酸受体-1(LYVE-1)的表达与胃癌临床病理特征的关系及临床意义。方法 应用组织微阵列技术(TMA),免疫组化SP法检测125例胃癌组织标本、96例癌旁正常组织、20例胃良性病变和胃癌癌周600枚淋巴结中VEGF-C、VEGFR-3和LYVE-1蛋白的表达。结果 三指标在不同胃组织中的表达差异均有统计学意义(均P<0.01); 胃癌组织中VEGF-C、VEGFR-3及LYVE-1的阳性表达率分别为62.4%、56.0%及58.4%,明显高于胃良性病变(20.00%、30.0%及25.0%)和癌旁正常组织(10.41%、12.5% 及9.375%)中的表达(P<0.0083,χ2分割法),与胃癌癌周淋巴结中的表达差异无统计学意义(60%、56%及55%,均P>0.0083,χ2分割法)。VEGF-C、VEGFR-3及LYVE-1三者阳性表达在有无淋巴结转移、远处转移及临床分期间差异有统计学意义(P<0.05); Logistic多因素分析显示,VEGF-C 、VEGFR-3和LYVE-1是与胃癌分期和远处转移有关的危险因素。结论 胃癌组织中存在VEGF-C、VEGFR-3和LYVE-1的高表达,与胃癌的发生、发展及侵袭转移有关。
Abstract:
Objective To investigate the expression and clinical significance of VEGF-C, VEGFR-3 and LYVE-1 in gastric carcinoma. Methods The immunohistochemical was used to detect the VEGF-C, VEGFR-3 and LYVE-1 in 125 cases with gastric carcinoma, 96 cases with adjacent normal tissue, 20 cases with benign gastric lession and 600 cases with lymph nodes. Results The positive rates of VEGF-C, VEGFR-3 and LYVE-1 in gastric carcinoma tissue were 62.4%,56.0% and 58.4% and they were higher than those in benign gastric lesion tissue(20.0%,30%,25%)and in adjacent normal tissue(10.41%,12.50%,9.375%)(P<0.0083). There was significant difference among the expression of VEGF-C, VEGFR-3 and LYVE-1 in lymph node metastasis, distant metastasis and gastric cancer stage(P<0.05). Logistic regression analysis showed that the expression of VEGF-C, VEGFR-3 and LYVE-1 increased the risk of gastric cancer staging and distant metastasis. Conclusion The over expression of VEGF-C,VEGFR-3 and LYVE-1 in gastric carcinoma involved in gastric carcinogenesis and progress of the invasion process.

参考文献/References:

[1] Fromowitz FB,Viola MV,Chao S,et al. Ras P21 expression in the progression of breast cancer[J]. Hum Pathol,1987,18(12):1268-1275.
[2] Karkkainen MJ,Haiko P,Sainio K,et al. Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins [J]. Nat Immunol,2004,5(1):74-80.
[3] Saharinen P,Tuomas T,Marika J,et al. Lymphatic vasculature:development,molecular regulation and role in tumor metastasis and inflammation[J]. Trends Immunol,2004,25(7)387-395.
[4] Banerji S,Ni J,Wang SX,et al. LYVE-1 a new homologue of the CD44 Glycoprotein,is a lymphspecific receptor for hyaluronan[J]. J Cell Biol,1999,144(4):789-801.
[5] 张艳红,尹奎夫,刘美华,等. 血管内皮生长因子-C 在胃癌中的表达及临床意义[J]. 社区医学杂志,2012,710(14):24-25.
[6] 杨静,景在平. 血管内皮生长因子受体表达水平与胃癌临床病理学特征的关系[J]. 中国医药导报,2011,8(22):16-18.
[7] 苏川妮,李清,彭建中,等. VEGF-C和VEGFR-3在胃癌组织中的表达及临 床意义[J]. 现代生物医学进展,2011,11(7):1340-1342.
[8] Fusun Ozmen, M Mahir Ozmen,Evren Ozdemir,et al. Relationship between LYVE-1, VEGFR-3 and CD44 gene expressions and lymphatic metastasis in gastric cancer[J],World Journal of Gastroenterology,2011,17(27):3220-3228.
[9] Tsutsumi S, Kuwano H,Shimura T,et al.Vascular endothelial growth factor C(VEGF-C)expression in pT2 gastric cancer[J].Hepatogas-troenterology,2005, 52(62):629-632.

相似文献/References:

[1]张少华,刘晓霞,陈利萍,等.E-cadherin在基底细胞样乳腺癌组织中的表达及意义[J].宁夏医科大学学报,2012,(03):257.
 ZHANG Shao-hua,LIU Xiao-xia,CHEN Li-ping,et al.Expression and Significance of E-cadherin in Basal-like Breast Carcinoma Tissue[J].Ningxia Medical University,2012,(04):257.
[2]孙伯坚,王淑静,马佰菁,等.赖氨酰氧化酶对荷胃癌裸鼠肿瘤形成和转移的影响[J].宁夏医科大学学报,2012,(03):219.
 SUN Bo-jian,WANG Shu-jing,MA Bai-jing,et al.Effect of Lysyl Oxidase on Tumorigenesis and Tumor Metastasisin Gastric Tumor-bearing Nude Mice[J].Ningxia Medical University,2012,(04):219.
[3]马亚军,张艳丽,崔 柳,等.TLR9表达与胃癌临床病理特征关系的初步研究[J].宁夏医科大学学报,2012,(02):125.
 MA Ya-jun,ZHANG Yan-li,CUI-liu,et al.Relationship between TLR9 and Clinicopathologic Features in Patients with Gastric Cancer[J].Ningxia Medical University,2012,(04):125.
[4]王平,陈晓霞.胃病患者检测幽门螺杆菌及血清胃蛋白酶原的意义[J].宁夏医科大学学报,2013,(11):1294.
[5]冯雅宁,武传霞,白芳云,等.ApoG2对胃癌细胞SGC7901粘附与迁移的影响及机制研究[J].宁夏医科大学学报,2013,(11):1240.
 FENG Yaning,WU Chuanxia,BAI Fangyun,et al.Effect of ApoG2 on the Adhesion and Migration of Gastric Cancer Cell Line SGC7901[J].Ningxia Medical University,2013,(04):1240.
[6]师红利,王 海,姜荣兴,等.多肽pd20分子胃癌肝转移导向性的体内特异性鉴定[J].宁夏医科大学学报,2013,(10):1076.
 SHI Hongli,WANG Hai,JIANG Rongxing,et al.Specific Identification of Polypeptide Pd20 Target to Gastric Cancer with Liver Metastasis[J].Ningxia Medical University,2013,(04):1076.
[7]车 杨,郭天康,马云涛,等.DLC-1与MMP-9在胃癌黏膜中的表达及临床意义[J].宁夏医科大学学报,2013,(08):872.
 CHE Yang,GUO Tiankang,MA Yuntao,et al.Expression and Clinical Significance of DLC-1 and MMP-9 in Gastric Carcinoma[J].Ningxia Medical University,2013,(04):872.
[8]吕永涛,宁天江,邓子兵,等.宁夏青铜峡市胃癌高危人群防治知识认知度分析[J].宁夏医科大学学报,2013,(05):560.
[9]田兆荣,郭玉林.35例进展期胃癌的高场强磁共振影像分析[J].宁夏医科大学学报,2013,(04):442.
[10]张少华,刘晓霞,墙 华,等.EZH2和FOXC1在基底细胞样型乳腺癌中的表达及其意义[J].宁夏医科大学学报,2013,(01):9.
 ZHANG Shao-hua,LIU Xiao-xia,QIANG Hua,et al.Expression and Clinical Pathological Features of EZH2 and FOXC1 in Basal-like Breast Cancer[J].Ningxia Medical University,2013,(04):9.

备注/Memo

备注/Memo:
收稿日期:2012-10-27 基金项目:宁夏自然科学基金项目(NZ0899) 作者简介:赵艳姣(1988-),女,在读硕士研究生,从事肿瘤化疗专业。 通信作者:刘新兰,教授,主任医师,硕士生导师。E-mail:liuxinlan@csco.org.cn
更新日期/Last Update: 2013-04-20