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[1]张艳玲,武永利,闫 安,等.温针灸对膝骨性关节炎患者血清中IGF-1、TGF-β 和FGF-2 表达水平影响的研究[J].宁夏医科大学学报,2013,(02):177-180.
 ZHANG Yan-ling,WU Yong-li,YAN An,et al.Study on Influence of Temperature Acupuncture on Knee Osteoarthritis Patients Serum IGF-1, TGF-β and FGF-2 Expression Level[J].Ningxia Medical University,2013,(02):177-180.
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温针灸对膝骨性关节炎患者血清中IGF-1、TGF-β 和FGF-2 表达水平影响的研究(PDF)
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《宁夏医科大学学报》[ISSN:1005-8486/CN:64-1029/R]

卷:
期数:
2013年02期
页码:
177-180
栏目:
论著
出版日期:
2013-02-20

文章信息/Info

Title:
Study on Influence of Temperature Acupuncture on Knee Osteoarthritis Patients Serum IGF-1, TGF-β and FGF-2 Expression Level
作者:
张艳玲1 武永利2 闫 安3 唐 朝2
1.宁夏医科大学,银川 750004; 2.宁夏医科大学总医院中医骨伤科,银川 750004; 3.宁夏第五人民医院中医科,石嘴山 753000
Author(s):
ZHANG Yan-ling1 WU Yong-li2 YAN An3 TANG Chao2
1.Ningxia Medical University,Yinchuan 750004; 2.Dept. of Chinese Orthopedics, the General Hospital of Ningxia Medical University,Yinchuan 750004; 3.Dept. of Traditional Chinese Medicine, the Fifth Ningxia People's Hospital, Shizui-shan 753000
关键词:
温针灸 膝骨性关节炎 IGF-1 TGF-β FGF-2
Keywords:
warming needle moxibustion knee osteoarthritis IGF-1 TGF-β FGF-2
分类号:
R245
DOI:
-
文献标志码:
A
摘要:
目的 观察温针灸治疗膝骨性关节炎(knee osteoarthritis,KOA)的疗效并比较治疗前后患者血清转化生长因子-β(transforming growth factor-β,TGF-β)、胰岛素样生长因子-1(insulin-like growth factor-1,IGF-1)和成纤维细胞生长因子-2(fibroblast growth factor-2,FGF-2)的水平,探讨温针灸治疗膝骨性关节炎的机理。方法 80例KOA患者随机分为温针灸治疗组和双氯芬酸钠药物对照组,每组各40例,收集治疗前后患者血清,用双抗体夹心酶联免疫吸附法检测温针灸治疗KOA患者血清IGF-1、TGF-β和FGF-2水平。结果 温针灸和口服双氯芬酸钠均能使KOA 患者临床症状减轻( 均P<0.05),并且前者在改善患者临床症状方面优于后者; 温针灸治疗KOA后,患者血清中IGF-1、TGF-β和FGF-2含量明显升高(均 P<0.05)。结论 温针灸对KOA 的疗效与其调高患者血清中IGF-1、TGF-β和FGF-2水平有关。
Abstract:
Objective To compare the serum IGF-1, TGF-β and FGF-2 expression level that before and after warming needle moxibustion treatment in patients with knee osteoarthritis(KOA), and to explore the mechanism of warming needle moxibustion in treating KOA. Methods 80 cases were randomly divided into warming needle moxibustion treatment group and drugs control group. Blood samples were collected before and after warming needle moxibustion treatment. Serum IGF-1, TGF-β and FGF-2 level were detected with ELISA. Results Improvement of clinical symptoms in patients in the warming needle moxibustion group were found significantly better than that in control group(P<0.05). IGF-1, TGF-βand FGF-2 level increased significantly after warming needle moxibustion treatment(P<0.05). Conclusion The curative effect of warming needle moxibustion in treating KOA is related to promote the serum IGF-1, TGF-β and FGF-2 level in patients.

参考文献/References:

[1] 赵强,冯伟,蔡宝君.国内温针治疗膝关节骨性关节炎疗效的系统评价[J].辽宁中医药大学学报,2010,12(4):49.
[2] 施桂英.关节炎概要[M].北京:中国医药科技出版社,2005:442-443.
[3] 徐卫东,吴岳篙,张春才.骨关节炎的诊断与治疗[M].上海:第二军医大学出版社,2004:140-141.
[4] 徐欣,洪昆达,吴明霞,等.温针灸对肾虚髓亏型膝骨性关节炎关节滑液MMP-3 与细胞因子的影响[J].福建中医学院学报,2009,19(6):42-45.
[5] 卫荣,迪丽娜尔·马合木提,杨少玲,等.维医沙疗对兔膝骨关节炎血液流变学和血液动力学影响[J].科技导报,2009,27( 3):83-86.
[6] 陈益丹,邱华平,金肖青,等.温针灸对兔膝骨关节炎模型基质金属蛋白酶及组织形态学影响的实验研究[J]. 中华中医药学刊,2011,29(5):1060-1062.
[7] 彭丹,孙材江,周江南,等. NO在实验性骨关节炎软骨凋亡中的作用[J].中华风湿病杂志,2000,4(4):232-234.
[8] Faw th rop FW,Frazer A,Russell RG,et al. Effects of transfor-ming growth factor beta on the production of prostag land in E and case inase activity of unstimulated and interleuk in-1 stimulated human articular chondrocytes in culture[J ]. Br J Rheumato,1997,36(7):729-734.
[9] 郭静,李琪佳.基质金属蛋白酶13和转化生长因子β1 mRNA及蛋白在骨性关节炎中的表达[J].第四军医大学学报,2009,30(22):2626-2630.
[10] Lis K,Odrowaz-Sypniew ska G,Nowacki W.Evaluation of IGF-1 concentration in serum and synovial fluid in women with different type coxarthrosis [J].Chir Narzadow Ruchu Ortop Pol,2005,70(6):407-410.
[11] IwanagaH,MatsumotoT,EnomotoH,et al. Enhanced expression of insulin-like growth factor-binding proteins in human osteoarthritic cartilage detected by immunohistochemistry and in situ hybridization[J].Osteoarthritis Cartilage,2005,13(5):439-448.
[12] Montero A,Okada Y,Tomita M,et al. Disrupt ion o f the fibro blast gr ow th facto r- 2 g ene results in decreased bone mass and bo ne formation[J]. J Clin Invest,2000,105:1085-1093.

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备注/Memo

备注/Memo:
收稿日期:2012-05-25 基金项目:宁夏自然科学基金项目(NZ10127) 作者简介:张艳玲(1988-),女,硕士,主要从事针灸推拿防治退行性骨关节病的临床及实验工作。 通信作者:武永利(1968-),男,副教授,主任医师,硕士研究生导师,主要从事针灸推拿防治退行性骨关节病的临床及实验工作。
更新日期/Last Update: 2013-02-20