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[1]张茂先,袁 莉,杨海波,等.体外循环预充还原型谷胱甘肽在心脏瓣膜术中的心肌保护作用[J].宁夏医科大学学报,2012,(11):1175-1177.
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体外循环预充还原型谷胱甘肽在心脏瓣膜术中的心肌保护作用(PDF)
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《宁夏医科大学学报》[ISSN:1005-8486/CN:64-1029/R]

卷:
期数:
2012年11期
页码:
1175-1177
栏目:
经验交流
出版日期:
2012-11-30

文章信息/Info

Title:
-
作者:
张茂先1 袁 莉2 杨海波1 王 云1 叶青山1
1.宁夏人民医院麻醉科,银川 750021; 2.宁夏平罗县人民医院呼吸内科,平罗 753400
Author(s):
-
关键词:
还原型谷胱甘肽心脏瓣膜病体外循环心肌保护
Keywords:
-
分类号:
R654.2
DOI:
-
文献标志码:
B
摘要:
目的观察体外循环预充还原型谷胱甘肽对心脏瓣膜病患者术中的心肌保护作用。方法30例心脏瓣膜病患者随机分为两组,实验组(15例)在体外循环预充液中加入还原型谷胱甘肽(剂量1200mg),对照组(15例)在体外循环预充液中加入等量的盐水。分别于术前、主动脉开放2、12、24、48h共5个时间点采患者动或静脉血,分别测乳酸脱氢酶(LDH)、血清肌酸激酶(CK)、血清肌酸激酶同工酶(CK-MB)、天门冬氨酸转氨酶(AST)。结果实验组血清LDH在主动脉开放2、12、24、48h较相同时间的对照组有显著减低(P<0.05或<0.01);CK、AST在主动脉开放2、12、48h较相同时间的对照组有显著减低(P<0.05或<0.01);实验组血清CK-MB在主动脉开放2、24、48h较相同时间的对照组有显著减低(P<0.05或<0.01),差异具有统计学意义。结论体外循环预充还原型谷胱甘肽在心脏瓣膜手术中具有较好的心肌保护作用。
Abstract:
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参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2012-09-05 作者简介:张茂先(1975-),男,河南人,主治医师,从事麻醉科专业。
更新日期/Last Update: 2012-11-20