|本期目录/Table of Contents|

[1]袁莹莹,赵君利,刘 丽,等.体外受精助孕患者染色体核型特点分析[J].宁夏医科大学学报,2012,(08):779-782.
 YUAN Ying-ying,ZHAO Jun-li,LIU Li,et al.Clinical Analysis of Chromosomal Abnormalities among Patients Undergoing in Vitro Fertilization-embryo Transfer[J].Ningxia Medical University,2012,(08):779-782.
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《宁夏医科大学学报》[ISSN:1005-8486/CN:64-1029/R]

卷:
期数:
2012年08期
页码:
779-782
栏目:
论著
出版日期:
2012-08-30

文章信息/Info

Title:
Clinical Analysis of Chromosomal Abnormalities among Patients Undergoing in Vitro Fertilization-embryo Transfer
作者:
袁莹莹1 赵君利23 刘 丽1 成 洁1 景万红23
1.宁夏医科大学,银川 750004; 2.宁夏医科大学总医院生殖医学中心,银川 750004; 3.宁夏医科大学 宁夏生殖与遗传重点实验室、宁夏医科大学生育力保持省部共建教育部重点实验室,银川 750004
Author(s):
YUAN Ying-ying1 ZHAO Jun-li23 LIU Li1 CHENG Jie1 JING Wan-hong23
1. Ningxia Medical University,Yinchuan 750004; 2.The General Hospital of Ningxia Medical University,Yinchuan 750004; 3.Key Laboratory of Genetic and Reproduction, Ningxia Hui Autonomous Region,Key Laboratory of Fertility Preservation and Maintenance, M
关键词:
染色体 不孕 体外受精-胚胎移植 卵泡浆内单精子显微注射-胚胎移植
Keywords:
chromosome infertility in vitro fertilization-embryo transfer intracytoplasmic sperm injection-embryo transfer
分类号:
Q813.4
DOI:
-
文献标志码:
A
摘要:
目的 分析体外受精助孕患者染色体多态及异常检出率及主要异常核型者的临床特征。方法 回顾性分析657对体外受精-胚胎移植/卵泡浆内单精子显微注射-胚胎移植(In vitro fertilization-embryo transfer /Intracytoplasmic sperm injection- embryo transfer, IVF-ET/ICSI-ET)治疗对象的核型,分析其多态及异常核型检出率,探讨主要异常核型与生殖异常的关系及Y染色体异常与精液质量的关系。结果 IVF/ICSI助孕患者中染色体核型多态及异常者的总检出率为8.07%。其中以Y染色体异常最常见,占8.52%,其次为1、9、16号染色体变异,占1.67%。不同多态及异常核型患者的临床特征不同。Y染色体多态及异常可影响精液质量。结论 IVF/ICSI助孕者中染色体核型多态及异常者的总检出率高于我国普通人群。染色体异常是不孕不育的重要因素之一,临床应予以重视。
Abstract:
Objective To analyze the detection rate of abnormal chromosome and the main clinical features of abnormal karyotype among patients undergoing in vitro fertilization-embryo transfer. Methods The chromosome karyotype were analyzed retrospectively for 657 infertile couples who underwent in vitro fertilization-embryo transfer. The prevalence and the significance of chromosomal abnormalities among patients undergoing In vitro fertilization-embryo transfer were analyzed.Results The prevalence of abnormal karyotype was 8.07% among patients treated by assisted reproductive technology. Y-chromosome abnormalities were the most common(8.52%).These patients with different chromosomal karyotype showed different clinical characteristics. Abnormal Y chromosome had significant influence on sperm motility. Conclusion The abnormal karyotype among infertility patients was significantly higher than that among the general population in china. Chromosome abnormity is one of the most important factors in patients with infertility.

参考文献/References:

[1] Carp H,Feldman B,Oelsner Q,et al.Parental karyotype and subsequent live births in recurrent miscarriage[J].Fertil Steril,2004,81(5):1296-1301.
[2] Sahin FI, Yilm az Z, Yuregir OO, et al. Chromosome heteromorphisms: an impact on infertility[J]. Assist Reprod Genet, 2008, 25(5):191-195.
[3] Yuce H, Tekedereli I, Elyas H. Cytogenetic results of recurrent spontaneous abortions in Turkey[J]. Med Sci Monit, 2007,13(6): 286-289.
[4] WHO. 人类精液及精子、宫颈粘液相互作用实验室手册[M].谷翊群,陈振文,于和鸣,等译.4版.北京:人民卫生出版社,2011:29-35.
[5] Carp H,Feldman B,Oelsner Q,et al.Parental karyotype and subsequent live births in recurrent miscarriage[J].Fertil Steril,2004,81(5):1296-1301.
[6] Bhasin M. Human population cytogenetics: a review Int [J].Hum Genet, 2005, 5(2):83-152.
[7] 张明, 高久春, 郑贤红, 等. 不良孕产史患者467例细胞遗传学分析[J]. 实用医学杂志, 2008, 24(6):998-1000.
[8] 刘京昇,赵静,郭淼,等.Y染色体异染色质区变异对表型和生育的影响 [J].中国现代医学杂志,2011,21(20):2396-2398.
[9] 敖良飞,徐望明,杨箐,等.男性大Y染色体核型对辅助生殖疗效的影响[J].武汉大学学报,2010,31(3):357-359.
[10] 潘倩莹,孙筱放,孔舒,等.9号染色体臂间倒位与流产、不孕不育关系的探讨[J].中华医学遗传学杂志,2007,(2):123.
[11] 赵君利,陆宏,焦海燕,等.男方9号染色体臂间倒位IVF助孕获得正常新生儿一例分析[J].宁夏医科大学学报, 2011,33(1):88-90.
[12] 彭亮,焦海燕,陈银涛.染色体技术在相关疾病临床诊断中的应用[J].宁夏医学院学报,2002,24(1):19-21.
[13] 赵君利,霍正浩, 胡蓉, 等. 罗伯逊易位重度少弱精子症ICSI助孕成功一例[J].宁夏医科大学学报, 2010.32(1):153-154.

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备注/Memo

备注/Memo:
收稿日期:2012-02-02 基金项目:宁夏自然科学基金(NZ0797、NZ11267) 作者简介:袁莹莹(1985-),女,在读硕士研究生,研究方向:生殖内分泌。 通信作者:赵君利,女,副教授,博士,从事生殖内分泌研究。 E-mail:zhaojunlii@yahoo.com.cn
更新日期/Last Update: 2012-08-20