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[1]王 妍,陈晓平,薛晓成,等.腮腺肿瘤中HPV37种亚型的分布[J].宁夏医科大学学报,2012,(06):596-599.
 WANG Yan,CHEN Xiao-ping,XUE Xiao-cheng,et al.Distribution of 37 Kinds of Human Papillomavirus Genotypes in Parotid Gland Tumors[J].Ningxia Medical University,2012,(06):596-599.
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《宁夏医科大学学报》[ISSN:1005-8486/CN:64-1029/R]

卷:
期数:
2012年06期
页码:
596-599
栏目:
论著
出版日期:
2012-06-30

文章信息/Info

Title:
Distribution of 37 Kinds of Human Papillomavirus Genotypes in Parotid Gland Tumors
作者:
王 妍1 陈晓平2 薛晓成1 张 燚2 陈 群2 张竞飞2
1.宁夏医科大学,银川 750004; 2.上海市浦东新区公利医院,上海 200135
Author(s):
WANG Yan1CHEN Xiao-ping2XUE Xiao-cheng1 ZHANG Yi2CHEN Qun2ZHANG Jing-fei2
1.Ningxia Medical University,Yinchuan 750004; 2.Shanghai Pudong New Area Gongli Hospital,Shanghai 200135
关键词:
腮腺肿瘤 人乳头瘤病毒 基因型 导流杂交基因芯片技术
Keywords:
parotid gland tumors human papillomavirus genotyping flow-through hybridization and gene chip
分类号:
R739.8
DOI:
-
文献标志码:
A
摘要:
目的 探讨腮腺肿瘤(Parotid Gland Tumor)与人乳头状瘤病毒(Human Papillomavirus,HPV)感染及其亚型的相关性。方法 采用核酸分子快速导流杂交基因芯片分型技术(Hybri Max)对59例腮腺肿瘤石蜡包埋组织标本进行37种HPV亚型检测,并以20例健康志愿者的正常口腔黏膜组织为对照。结果 腮腺肿瘤石蜡包埋组织标本HPV总检出率为57.6%(34/59),对照组均为阴性(0/20),两组比较差异有统计学意义(χ2=20.234,P<0.05); 腮腺良性、恶性肿瘤组织中HPV阳性率分别为59.6%(31/52)和42.9%(3/7),两组HPV阳性率比较差异无统计学意义(χ2=0.189,P>0.05); 腮腺肿瘤组中HPV感染亚型以高危亚型为主(80.7%),其中以HPV16、18、52型为主(61.4%); 腮腺肿瘤组中HPV单一亚型、多重亚型均可感染,但以混合亚型感染为主(52.9%)。结论 腮腺肿瘤的发生可能与HPV感染有相关性。腮腺肿瘤中HPV高、低危亚型均可感染,以高危亚型HPV16、18、52型感染为主。
Abstract:
Objective To investigate the distribution of HPV subtypes in the pariotid gland tumors and to evaluate the relationship between HPV and pariotid gland tumors. Methods 37 HPV subtypes were detected in paraffin-embedded tissues of 59 cases with parotid gland tumors by flow-through hybridization and gene chip(Hybrimax)technology. 20 cases of normal oral mucosa were used as controls. Results HPV general positive rate of pariotid gland tumors was 57.6%(34/59). The rate in control group were all negative(0/20). The HPV-positive rates of benign tumor and malignent tumor of pariotid gland were 59.6%(31/52)and 42.9%(3/7). The high-risk HPV(80.7%)was the most prevalent type in the group of parotid gland tumors and high-risk HPV-16/18/52 were mainly prevalent types(61.4%). Both single-HPV and multi-HPV genotype existed in the HPV-positive samples and most of cases(52.9%)were infected with multi-HPV genotype. Conclusion Incidence of parotid gland tumors may be related with HPV infection. Both high-risk HPV and low-risk HPV genotypes were identify in parotid gland tumors. High-risk HPV subtype was the main subtype in HPV-positive group and high-risk HPV-16/18/52 were mainly prevalent types.

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备注/Memo

备注/Memo:
收稿日期:2012-01-02 作者简介:王妍,在读硕士研究生。E-mail:xiaoshuaiai@yeah.net 通信作者:陈晓平。E-mail:chen_xp2000@163.com
更新日期/Last Update: 2012-06-20