|本期目录/Table of Contents|

[1]杨文君,陈志强,梁寒梅,等.p53 基因第72位密码子多态性与HPV相关食管鳞癌遗传易感性的研究[J].宁夏医科大学学报,2012,(05):444-447,452.
 YANG Wen-jun,CHEN Zhi-qiang,LIANG Han-mei,et al.The Correlation between p53 Codon 72 Polymorphism and the Risk of ESCC[J].Ningxia Medical University,2012,(05):444-447,452.
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p53 基因第72位密码子多态性与HPV相关食管鳞癌遗传易感性的研究(PDF)
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《宁夏医科大学学报》[ISSN:1005-8486/CN:64-1029/R]

卷:
期数:
2012年05期
页码:
444-447,452
栏目:
论著
出版日期:
2012-05-30

文章信息/Info

Title:
The Correlation between p53 Codon 72 Polymorphism and the Risk of ESCC
作者:
杨文君123陈志强4梁寒梅1齐奇1王银2贾伟4赵巍2王立东5叶晓锋4吕怀盛4
1. 宁夏医科大学基础学院生物技术系,银川750004;2. 宁夏医科大学科技中心,银川750004; 3. 宁夏医科大学生育力保持重点实验室,银川750004;4.宁夏医科大学总医院,银川750004;5.河南省郑州大学食管癌重点实验室,郑州452470
Author(s):
YANG Wen-junCHEN Zhi-qiangLIANG Han-meiQI QiWANG YinJIA WeiZHAO WeiWANG Li-dongYE Xiao-fengL Huai-sheng
Ningxia Medical University,Yinchuan 750004
关键词:
食管鳞癌p53多态性
Keywords:
ESCC p53 SNP
分类号:
R735.1
DOI:
-
文献标志码:
A
摘要:
目的 探究p53 基因第72位密码子(codon72)多态性与HPV相关食管鳞癌的关联性。方法选择435例食管鳞癌(Esophageal Squamous Cell Carcinoma,ESCC)患者和550例健康对照,进行p53 codon72与食管鳞癌发生的关联研究。结果病例组的Arg/Arg基因型的频率高于对照组(85.7% vs 49.6%);Arg/Arg基因型携带者发生食管鳞癌的风险是携带Arg/Pro或Pro/Pro基因型个体的6.48倍(P<0.001)。结论p53 codon72纯合子Arg/Arg可能是HPV相关食管鳞癌发生的危险因素。
Abstract:
Objective[WT5BZ]To address a potential correlation between the genotypes of p53 codon 72 and the risk of HPV related esophageal squamous cell carcinoma (ESCC).[WTHZ]Methods[WT5BZ]p53 codon 72 polymorphism in 435 patients with ESCC and 550 cancer-free subjects from the same geographical region were investigated.[WTHZ]Results[WT5BZ]p53 Arg/Arg genotype was significantly increased in ESCC cases compared with control subjects (857% vs 49.6%,P<0.001),resulting in an elevated ESCC risk (OR=6.48,95%,CI= 4.65~9.03).[WTHZ]Conclusion[WT5BZ]p53 Arg represents a potential risk for the development of HPV related ESCC.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2011-11-02 基金项目:国家自然科学基金(30860320,81160249,81160252,30960108);宁夏自然科学基金(NZ0880) 作者简介:杨文君(1973-),女(回族),副教授,博士,从事群体遗传学研究工作。 通信作者:叶晓锋(1963-),主任医师,从事胸部肿瘤研究工作。E-mail:yxf6312@sina.com
更新日期/Last Update: 2012-05-20