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[1]贺晓莉,朱玲勤,王伟红,等.过氧化物酶体增殖物激活受体γC161→T基因多态性 与代谢综合征的相关研究[J].宁夏医科大学学报,2012,(03):204-207,221.
 HE Xiao-li,ZHU Ling-qin,WANG Wei-hong,et al.Relationship of Peroxisome Proliferator Activated Receptor Gamma C161T Gene Polymorphism with Metabolic Syndrome[J].Ningxia Medical University,2012,(03):204-207,221.
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过氧化物酶体增殖物激活受体γC161→T基因多态性 与代谢综合征的相关研究(PDF)
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《宁夏医科大学学报》[ISSN:1005-8486/CN:64-1029/R]

卷:
期数:
2012年03期
页码:
204-207,221
栏目:
论著
出版日期:
2012-03-30

文章信息/Info

Title:
Relationship of Peroxisome Proliferator Activated Receptor Gamma C161T Gene Polymorphism with Metabolic Syndrome
作者:
贺晓莉 朱玲勤 王伟红 杨建军
宁夏医科大学公共卫生学院,银川 750004
Author(s):
HE Xiao-li ZHU Ling-qin WANG Wei-hong YANG Jian-jun
Ningxia Medical University,Yinchuan 750004
关键词:
氧化物酶体增殖物激活受体γ 基因多态性 代谢综合征
Keywords:
peroxisome proliferator activated receptor gamma gene polymorphism metabolic syndrome
分类号:
R587.1
DOI:
-
文献标志码:
A
摘要:
目的 探讨过氧化物酶体增殖物激活受体γ(PPARγ)基因C161→T多态性在宁夏人群中的分布及其与代谢综合征(MS)的关系。方法 运用横断面的调查的方法,选取175例健康对照者,平均年龄(47.30±11.6)岁和175例代谢综合征患者,平均年龄(48.73±12.50)岁,采用聚合酶链反应和限制性片段长度多态性方法(PCR-RFLP)检测人群中的PPARγ基因C161→T位点多态性,并对不同基因型患者代谢综合征的危险性进行评价。结果 ⑴代谢综合征组、对照组T等位基因频率分别为0.253、0.240,C等位基因频率分别为0.747、0.760; C、T等位基因频率在各组间分布差异无统计学意义; ⑵PPARγC161CC基因型的总胆固醇(TC)水平高于TT型。结论 PPARγC161→T基因多态性与代谢综合征有关,即代谢综合征患者CC基因型总胆固醇水平相对较高。
Abstract:
Objective To investigate the association of PPARγC161→T gene polymorphism with metabolic syndrome in Chinese people of Ninxia. Methods Cross-sectional survey method was used for investigation., The polymorphism of PPARγC161→T gene of 175 metabolic syndrome patients were determined by PCR-PFLP method to detect. The risk of metabolic syndrome with different genotypes was evaluated. Results ⑴ In the groups of metabolic syndrome and nomal health, “T” allele frequency was 0.253,0.240 respectively; and “C” allele frequency was 0.747,0.760 respectively.There was no significant difference between the groups. ⑵The total cholesterol in CC genotypes in patients with metabolic syndrome was significantly higher than that in TT. Conclusion PPARγC161→T gene polymorphism can influence the level of lipoprotain metabolism and FBS. CC allele is associated with higher level of total cholesterol it may influence the process of metabolic syndrome.

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备注/Memo

备注/Memo:
收稿日期:2011-09-21 基金项目:国家自然科学基金资助项目(81060235); 宁夏卫生厅科技项目 作者简介:贺晓莉(1985-),在读硕士研究生,研究方向:营养流行病学。 通信作者:杨建军,教授,研究方向:营养流行病学。E- mail:yangjianjun_1969@163.com
更新日期/Last Update: 2012-03-20