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[1]李继东,姚成立,宁海峰.还原型谷胱甘肽干预高同型半胱氨酸血症 致兔动脉粥样硬化的实验研究[J].宁夏医科大学学报,2010,(07):773-776.
 LI Ji-dong,YAO Cheng-li,NING Hai-feng.Glutathione Intervention Hyperhomocysteimia Induced Atherosclerosis in Rabbits[J].Ningxia Medical University,2010,(07):773-776.
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还原型谷胱甘肽干预高同型半胱氨酸血症 致兔动脉粥样硬化的实验研究(PDF)
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《宁夏医科大学学报》[ISSN:1005-8486/CN:64-1029/R]

卷:
期数:
2010年07期
页码:
773-776
栏目:
论著
出版日期:
2011-12-30

文章信息/Info

Title:
Glutathione Intervention Hyperhomocysteimia Induced Atherosclerosis in Rabbits
作者:
李继东1 姚成立2 宁海峰2
1.宁夏回族自治区第三人民医院,银川 750011; 2.银川市第一人民医院,银川 750001
Author(s):
LI Ji-dong1 YAO Cheng-li2 NING Hai-feng2
1.The Third People's Hospital of Yinchuan, Yinchuan 750011; 2.The First People's Hospital, Yinchuan 750001
关键词:
还原型谷胱甘肽 高同型半胱氨酸血症 动脉粥样硬化
Keywords:
reduced glutathione high Hyperhomocysteinemia atherosclerosis
分类号:
R363
DOI:
-
文献标志码:
A
摘要:
目的 探讨还原型谷胱甘肽干预高同型半胱氨酸血症致兔动脉粥样硬化的机制。方法 将44只新西兰白兔随机分为4组:对照组以标准饲料100 g·d-1喂养,模型组以1%蛋氨酸饲料100 g·d-1喂养,低剂量药物组以1%蛋氨酸饲料100g·d-1喂养+还原型谷胱甘肽15mg·d-1肌注,高剂量药物组以1%蛋氨酸饲料100g·d-1喂养+还原型谷胱甘肽30mg·d-1肌注。于实验前和实验8周后耳中央动脉采血检测Hcy、TC、TG、CRP、SOD并对结果进行分析。结果 模型组Hcy水平高于对照组,差异有统计学意义(P<0.05); 模型组SOD活性降低,与对照组比较差异有统计学意义(P<0.05); 模型组CRP值高于对照组,差异有统计学意义(P<0.05); 经还原型谷胱甘肽治疗,模型组IMT高于对照组(P<0.05); 低剂量药物干预组IMT较对照组有所增厚(P<0.05); 高、低剂量药物干预组IMT与模型组比较,差异有统计学意义(P<0.05)。结论 还原型谷胱甘肽通过抑制氧化应激、炎症反应阻止动脉粥样硬化的发生、发展。
Abstract:
Objective To explore the mechanism of atherosclerosis of Rabbit induced by Hyperhomocysteinemia. Methods 44 New Zealand white rabbits were randomly divided into 4 groups: the control group(A group)were given standard feed; the model group(B group)took 1% methionine diet 100 g·d-1 feeding; low-dose intervention group(C group)took 1% methionine diet 100g·d-1 feeding + Reduced Glutathione 15mg·d-1intramuscularly; high-dose intervention group(D group)took 1% methionine diet 100g·d-1 feeding + Reduced Glutathione 30mg·d-1intramuscularly. at 0 and the 8th week, rabbit central ear artery blood were taken and plasma total homocysteine levels, serum total cholesterol, triglyceride, C-reactive protein, super-oxide dismutase were detected. Results Plasma Hcy and C-reactive protein were significantly higher than those in control group.(P<0.05). SOD activity were significantly lower than those in control group(P<0.05). Glutathione intervention could reduce the serum Hcy concentrations and raise SOD activity(P<0.05). Conclusion Glutathione can prevent the occurrence and development of atherosclerosis development by inhibiting the oxidative stress and inflammatory response.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2010-03-29 基金项目:银川市科技攻关项目(2010028) 作者简介:李继东,主治医师,硕士,从事心血管专业研究。 通信作者:姚成立,教授,硕士研究生导师,主任医师,从事心血管专业研究。
更新日期/Last Update: 2010-07-20