|本期目录/Table of Contents|

[1]张 东,杨 春,杨银学,等.Claudin-2在大肠癌中的表达及其与临床病理特征的关系[J].宁夏医科大学学报,2010,(05):600-602.
 ZHANG Dong,YANG Chun,YANG Yin-xue,et al.Expression of Claudin-2 in Colorectal Cancer Tissues and Its Relationship with Clinicopathological Properties[J].Ningxia Medical University,2010,(05):600-602.
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《宁夏医科大学学报》[ISSN:1005-8486/CN:64-1029/R]

卷:
期数:
2010年05期
页码:
600-602
栏目:
论著
出版日期:
2011-12-30

文章信息/Info

Title:
Expression of Claudin-2 in Colorectal Cancer Tissues and Its Relationship with Clinicopathological Properties
作者:
张 东1 杨 春1 杨银学1 张宁妹2 李 海1 蒋 波1 马晓强1 杨 萍1
1.宁夏医科大学附属医院结直肠外科,银川 750004; 2.宁夏医科大学附属医院病理科,银川 750004
Author(s):
ZHANG DongYANG Chun YANG Yin-xue et al
The Affiliated Hospital of Ningxia Medical University, Yinchaun 750004
关键词:
紧密连接蛋白 大肠癌 免疫组织化学
Keywords:
colorectal cancer claudin immunohistochemistr
分类号:
R735.3+4
DOI:
-
文献标志码:
A
摘要:
目的 观察紧密连接蛋白 Claudin-2在大肠癌组织中的表达及其与大肠癌发生和发展的关系。方法 运用免疫组化技术检测Claudin-2在大肠癌及癌旁组织、正常组织中的表达,并分析Claudin-2蛋白表达与大肠癌临床各病理特征的关系。结果 Claudin-2在大肠癌组织中的阳性表达率明显高于癌旁组织及正常组织(P<0.05)。Claudin-2在大肠癌组织中的阳性表达与肿瘤的分化程度、Dukes分期密切相关(P<0.05)。结论 大肠癌与癌旁组织及正常组织相比,Claudin-2表达阳性率明显升高,其改变在大肠癌的发生发展中可能起重要作用。
Abstract:
Objective To observe the expression of Claudin-2 in colorectal cancer tissues and to explore its relationship with the development and progression of colorectal cancer. Methods Immunohistochemical staining(SP method)was used to detect the expression of Claudin-2 in colorectal cancer tissue, adjacent normal tissue of colorectal cancer and normal tissue and investigate the correlation between expression of Claudin-2 in colorectal cancer tissue and the genesis and development of colorectal cancer. Results The expression of Claudin-2 in colorectal cancer tissues was significantly higher than those in the adjacent tissues of colorectal cancer and normal colorectal tissue(P<0.05); besides, the expression of Claudin-2 in the colorectal cancer tissue was correlated with degree of differentiation, Dukes stages of colorectal cancer(P<0.05). Conclusion The expression of Claudin-2 in colorectal cancer increases significantly in both positive rate and intensity compared with that in normal tissue. The higher expression of Claudin-2 may play an important role in the genesis and development of colorectal cancer.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2009-10-29 基金项目:宁夏高等学校科学研究项目(2005)。 作者简介:张东(1961-),男,主任医师,从事大肠癌的研究工作。 通信作者:杨银学(1960-),男,教授,博士,硕士生导师,从事大肠癌和工商管理研究工作。
更新日期/Last Update: 2010-05-20