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[1]周 丽,杨明武,李继东,等.高频超声检测高同型半胱氨酸血症兔模型 动脉粥样硬化的实验研究[J].宁夏医科大学学报,2010,(05):593-595,599.
 ZHOU Li,YANG Ming-wu,LI Ji-dong,et al.Experimental Study of Atherosclerosis in Rabbit Model with Hyperhomocysteinemia by High Resolution Ultrasound[J].Ningxia Medical University,2010,(05):593-595,599.
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高频超声检测高同型半胱氨酸血症兔模型 动脉粥样硬化的实验研究(PDF)
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《宁夏医科大学学报》[ISSN:1005-8486/CN:64-1029/R]

卷:
期数:
2010年05期
页码:
593-595,599
栏目:
论著
出版日期:
2011-12-30

文章信息/Info

Title:
Experimental Study of Atherosclerosis in Rabbit Model with Hyperhomocysteinemia by High Resolution Ultrasound
作者:
周 丽1 杨明武1 李继东2 刘 霞1
1.宁夏医科大学附属医院心脏中心超声心动室,银川 750004; 2.宁夏医科大学,银川 750004
Author(s):
ZHOU Li YANG Ming-wu LI Ji-dong et al
The Affiliated Hospital of Ningxia Medical University, Yinchuan 750004
关键词:
高同型半胱氨酸血症 动脉粥样硬化 超声 病理
Keywords:
hyperhomocy steimemia atherosclerosis ultrsound pathology
分类号:
Q95-33
DOI:
-
文献标志码:
A
摘要:
目的 探讨高频超声诊断兔模型动脉粥样硬化的价值。方法 将实验兔随机分为两组,每组10只,对照组喂以标准兔饲料,造模组喂以含1%蛋氨酸饲料,并于造模前及造模后8周测定血清中Hcy 和血脂,应用高频超声检测高同型半胱氨酸血症兔模型腹主动脉全程的内-中膜厚度(internal-media thickness, IMT)、斑块大小等,并与病理结果相对照。结果 造模组8周后血清中Hcy明显高于对照组,而血脂水平无明显差异,高频超声检测造模组血管内-中膜明显增厚,粗糙不光整,但未见明显粥样斑块形成。病理亦可见内-中膜增厚、粗糙,内膜中断,肌层平滑肌细胞空泡变性等早期动脉粥样硬化表现。结论 高频超声可以在粥样硬化斑块形成之前检测到血管内膜的改变,具有早期诊断动脉粥样硬化的价值。
Abstract:
Objective To investigate the relation between homocysteine and the development of atherosclerosis to explore the experimental method of establishing the model rabbit with hyperhomocy steimemia and to evaluate the role of high resolution ultrasound. Methords All of rabbits were randomly divided into two groups. Control group were fed with standard diet and the model group with containing 1% methionine diet Before and after model establishment 8 weeks the Hcy and blood lipid were cheched and the high resolution ultrasound were performed to measure the internal-media thickness, the size of the stenosis and plaque of all the abdominal aorta wall respectively. The results of ultrasound were compared with the pathologic results. Results The Hcy of model group in blood were higher than that of the controls,but there were no significant differences in blood lipid. Resolution ultrasound could accurately measure IMT and monitor the change of IMT, but no obvious stenosis and plaque were found. These changes also could be confirmed by pathologic results. Conclusion Hyperhomocysteinemia is an independent risk factor of Atherosclerosis and ultrasound can detect the changes of vessel wall before the stenosis and plaque forming.

参考文献/References:

[1] 鲁洋,李淑梅,张小昊,等. 同型半胱氨酸水平对冠心病的影响[J]. 中国老年学杂志, 2010, 30(1):101-102.
[2] 汤勇,杜安全,沈英,等. 同型半胱氨酸与血脂水平及在冠心病中的相关性研究[J]. 实验与检验医学, 2009,27(4):413-435.
[3] 左慧敏, 刘贵京, 魏红, 等. 高同型半胱胺酸与心血管疾病的相关研究述要[J]. 中医药学刊, 2003,21(4): 600-602.
[4] 黄荣宁,周祖文.同型半胱胺酸与心脑血管疾病关系的研究进展[J]. 右江医学,2005,33(5):527-528.
[5] Lentz SR, Malinow MR, Piegors DJ, et al. Consequences of hyperhomocysteinemia in vascular function in atherosclerotic monkeys[J]. Arterioscler Thromb Vac Biol,1997,17(2):930-934.
[6] Young PB, Kennedy S, Molloy AM, et al. Lipid peroxidation induced in vivo by hyperhomocysteinaemin in pigs[J]. Atherosclerosis, 1997,129:67-71.
[7] 李丽帆, 顾国龙, 吴芳, 等. 同型半胱胺酸致兔动脉粥样硬化的实验研究[J].广西医学, 2007,29(5):625-626.
[8] 徐叔云, 卞如濂, 陈修. 药理学实验方法[M]. 3版. 北京: 人民卫生出版社:202.
[9] 王兴华, 高奋, 李杰,等. 高同型半胱氨酸兔模型腹主动脉超声表现的实验研究[J]. 中华超声影像学杂志, 2003, 12(7): 435-437.
[10] 王家祥, 方平, 肖湘生, 等. 超声评价兔动脉粥样硬化的实验研究[J]. 中国医学影像技术,2006,22(2): 212-215.

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备注/Memo

备注/Memo:
收稿日期:2009-10-09 作者简介:周丽,女,主治医师,从事超声临床诊断工作。
更新日期/Last Update: 2010-05-20