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[1]杨建军,丁慧敏,王伟红,等.同型半胱氨酸与脑卒中、冠心病、高血压的相关性研究[J].宁夏医科大学学报,2010,(01):78-82.
 YANG Jian jun,DING Hui min,WANG Wei hong,et al.Relationship Between Homocysteine Levels and Stroke, Coronary Heart Disease and Hypertension[J].Ningxia Medical University,2010,(01):78-82.
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同型半胱氨酸与脑卒中、冠心病、高血压的相关性研究(PDF)
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《宁夏医科大学学报》[ISSN:1005-8486/CN:64-1029/R]

卷:
期数:
2010年01期
页码:
78-82
栏目:
论著
出版日期:
2011-12-30

文章信息/Info

Title:
Relationship Between Homocysteine Levels and Stroke, Coronary  Heart Disease and Hypertension
作者:
杨建军1丁慧敏2王伟红1王丽茹2张毓洪1陶秀娟1石 学宁2
1宁夏医科大学公共卫生学院,银川 750004; 2宁夏医科大学附属医院,银川 750 004
Author(s):
YANG Jianjun1 DING Huimin2 WANG Weihong1 et al
1.Department of Nutrition & Food Hygiene of Ningxia Medical Universit y, Yinchu an 750004; 2 .The Affiliated Hospital of Ningxia Medical University, Yinchuan 750004
关键词:
同型半胱氨酸冠心病高血压脑卒中危险因素
Keywords:
homocysteine coronary heart disease hypertension cerebral inf arction
分类号:
R541.4
DOI:
-
文献标志码:
A
摘要:
目的 探讨血清同型半胱氨酸(Hcy)与脑卒中、冠心病、高血压疾病 的关系及Hcy水平 升高对心脑血管疾病的影响。方法 本文运用流行病学病例对照及病例内 病例对照的研究方 法,采用循环酶法测定169例脑卒中、冠心病、高血压疾病患者及49例健康者的Hcy,并同时 测定其体质指数及相关临床生化指标。结果 脑卒中、冠心病、高血压患 者的Hcy水平明显高 于对照组(P<001);高同型半胱氨酸血症(HHcy)的发生率(693%、800%、735%) 均明显高于对照组(449%),P<001;高同型半胱氨酸血症患者中脑卒中组收缩压、 血 糖水平明显增高(P<005);冠心病组HDL-C水平降低,而血糖和尿酸水平明显增高( P<005);高血压组收缩压、舒张压、TC、T G、尿酸水平明显高于对照组(P<00 5)。多元线性回归分析仅显示冠心病组同型半胱氨酸水平与HDL-C相关(P<005)。 结论 脑卒中、冠心病、高血压患者血清Hcy水平明显增高,提示HHcy可能 是脑卒中、冠心病、高血压的独立危险因素。
Abstract:
Objective To investigate the relationship between the levels of serum homocysteine (Hcy) and stroke, coronary heart disease and hypertension and to o bserve effects of the different levels of serum Hcy on these diseases. Me thods Serum Hcy were measured by the circulation enzyme rate method. Casecontrol st u dy and casecasecontrol study were used to analyze the relationship between d is eases and factors. Results The levels of Hcy in cases were higher than that of control group (P<001). The prevalence rate of high homocysteine in three diseas es was 69.3%, 80.0% and 73.5% respectively and those were significantly higher t han that in control group (44.9%, P<001).The significant raise was found in sys tolic blood pressure and blood sugar in stroke group with HHcy. In CHD group , s ignificant drop was found in HDLC and significant raise was found in blood gl u cose and uric acid. In hypertension group, significant raise were found in systo lic blood pressure, diastolic blood pressure, TC, TG, uric acid (P<005). Multiv ariate linear regression analysis showed the significant difference in levels of HDLC between CHD group and controls (P<005). Conclusion The results showed t hat HHCY may be the independent risk factor for stroke, coronary heart disease a nd hypertension.

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备注/Memo

备注/Memo:
收稿日期: 2009-08-13基金项目:宁夏自然科学基金项目(NZ0774) 作者简介:杨建军(1969-),男,副教授,主要从事营养与慢性病的研究工作。E-ma il :yangjj@nxmu.edu.cn
更新日期/Last Update: 2010-01-20