|本期目录/Table of Contents|

[1]周翔鱼,杜彦辉.内皮型一氧化氮合酶基因多态性与宁夏地区缺血性脑血管病的相关性分析[J].宁夏医科大学学报,2009,(03):306-307,314.
 ZHOU Xiang-yu,DU Yan-hui.-[J].Ningxia Medical University,2009,(03):306-307,314.
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内皮型一氧化氮合酶基因多态性与宁夏地区缺血性脑血管病的相关性分析(PDF)
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《宁夏医科大学学报》[ISSN:1005-8486/CN:64-1029/R]

卷:
期数:
2009年03期
页码:
306-307,314
栏目:
论著
出版日期:
2009-06-20

文章信息/Info

Title:
-
作者:
周翔鱼;杜彦辉;
宁夏医科大学附属医院神经内科;
Author(s):
ZHOU Xiang-yuDU Yan-hui
The Affiliated Hospital of Ningxia Med.Univ.,Yinchuan 750004
关键词:
内皮型一氧化氮合酶基因多态性缺血性脑血管病
Keywords:
-
分类号:
R743.3
DOI:
-
文献标志码:
-
摘要:
目的研究内皮型一氧化氮合酶(eNOS)基因多态性与宁夏地区人群缺血性脑血管病之间的关系。方法应用聚合酶链反应(PCR)法对宁夏地区596例健康对照者、468例缺血性脑血管病患者的eNOS基因第4内含子可变重复序列多态性(VNTR)进行基因型分析。结果两组人群eNOS基因第4内含子VNTR表现为eNOS4a/4a,eNOS4a/4b,eNOS4b/4b3种基因型。在缺血性脑卒中患者中aa基因型频率为2.7%,ab基因型频率为18.7%,bb基因型频率为78.6%;对照组中aa基因型频率为1.2%,ab基因型频率为13.6%,bb基因型频率为85.2%。a等位基因频率在患者组和对照组分别为12.1%和8.0%,经χ2检验,二组间基因型频率a等位基因频率分布差异有统计学意义(χ2=9.122,P=0.010;χ2=10.008,P=0.002)。结论eNOS4a基因携带与宁夏地区人群缺血性脑血管病的发生有关联性。
Abstract:
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参考文献/References:

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备注/Memo

备注/Memo:
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更新日期/Last Update: 2009-05-20