|本期目录/Table of Contents|

[1]马云帆,郭德和,韩育宁.血必净注射液对体外循环期间细胞因子TNF-α和IL-6的影响[J].宁夏医科大学学报,2008,(04):440-442.
 MA Yun fan,GUO De he,HAN Yu ning.The Effects of Xuebijing Injection on Cytokines TNF-α, IL-6 During Cardiopulmonary Bypass[J].Ningxia Medical University,2008,(04):440-442.
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《宁夏医科大学学报》[ISSN:1005-8486/CN:64-1029/R]

卷:
期数:
2008年04期
页码:
440-442
栏目:
论著
出版日期:
2008-07-20

文章信息/Info

Title:
The Effects of Xuebijing Injection on Cytokines TNF-α, IL-6 During Cardiopulmonary Bypass
作者:
马云帆郭德和韩育宁
宁夏医学院附属医院胸心外科,银川750004
Author(s):
MA YunfanGUO DeheHAN Yuning
Dept of Cardiothoracic Surgery,the Affiliated Hospital of Ningxia Med Col l,Yinchuan 750004
关键词:
血必净注射液体外循环炎性反应综合征细胞因子TNF -αIL-6
Keywords:
Xuebijing injectioncardiopulmonary bypasssystemic i nfl ammatory response syndromecytokinestumor necrosis factor-αinterleukin-6
分类号:
R6541
DOI:
-
文献标志码:
A
摘要:
目的 观察血必净注射液对体外循环(CPB)期间肿瘤坏死因子-α( TNF-α)和白细胞介 素-6(IL-6)的影响。方法 选择30例心脏瓣膜置换术患者,随机分成实 验组和对照组(每组 15例)。实验组患者于术前晚、CPB前分别予血必净注射液100mL静滴,对照组予生理盐水静 滴 。于CPB前、CPB 30min、CPB停机、停机后2h、6h、24h采用放射免疫法测定两组血清中TNF- α和IL-6的浓度。结果 实验组TNF-α、IL-6血清浓度较对照组降低 ,差异有统计学意义( P<001)。结论 血必净注射液能减少CPB期间TNF-α和IL-6的释 放,减轻全身炎性反应的程度。
Abstract:
Objective To investigate the effects of Xuebijing injection on tumor necrosis factor-alpha(TNF-α)and interleukin-6(IL-6)during cardiopulmonary by pass(CPB). Methods Thirty patients undergoing valve replacement were randomly d ivided into Xuebijing group and control group(15 in each group).In Xuebijing gr oup,intravenous drip of 100 ml of Xuebijing injection were given at night befor e operation and before CPB,respectively,while in control group 09% NaC1 so lu tion was given as a placebo.Blood samples were taken before CPB,30min after CP B and 0h,2h,6h,24h after the end of CPB The serum levels of TNF-α and IL-6 wer e measured by radioimmunoassay method in two groups. Results The serum levels o f TNF-α and IL-6 in Xuebijing group were significantly lower than that in contr ol group(P<001) Conclusion The study demonstrated that X uebijing injection could reduce the release of TNF-α,IL-6 and inhibit systemic inflammatory resp onse syndrome(SIRS) during CPB

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备注/Memo

备注/Memo:
收稿日期:2007-07-11 作者简介:马云帆(1974-),男(回族),宁夏人,主治医师,硕士,从事胸心 外科专业。
更新日期/Last Update: 2008-07-20