|本期目录/Table of Contents|

[1]赵瑞宁,陈福宝,秦靖,等.Survivin在膀胱移行细胞癌中的表达及与DNA倍体的相关性研究[J].宁夏医科大学学报,2008,(04):415-417.
 ZHAO Rui ning,CHEN Fu bao,QIN Jing,et al.Expression and Analysis of Survivin and DNA Ploidy Analysis in Bladder Transitional Carcinoma[J].Ningxia Medical University,2008,(04):415-417.
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Survivin在膀胱移行细胞癌中的表达及与DNA倍体的相关性研究(PDF)
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《宁夏医科大学学报》[ISSN:1005-8486/CN:64-1029/R]

卷:
期数:
2008年04期
页码:
415-417
栏目:
论著
出版日期:
2008-07-20

文章信息/Info

Title:
Expression and Analysis of Survivin and DNA Ploidy  Analysis in Bladder Transitional Carcinoma
作者:
赵瑞宁1陈福宝1秦靖2杨芝 红3张宁妹2师宏斌1余洋1卢冠军1
1宁夏医学院附属医院泌尿外科,银川750004;2宁夏医学院附属医院病理科,银 川750004;3宁夏医学院附属医院中心实验室,银川750004
Author(s):
ZHAO RuiningCHEN FubaoQIN Jinget al
Dept of Urology,the Affiliated Hospital of Ningxia Med Coll,Yinchuan 750004
关键词:
膀胱肿瘤SurvivinDNA倍体免疫组化流式细胞术
Keywords:
bladder neoplasmsurvivinDNA ploidyimmunohistochemistry flow cytometry
分类号:
R73714
DOI:
-
文献标志码:
A
摘要:
目的 探讨Survivin表达和DNA倍体分析在膀胱移行细胞癌中的临 床意义及相关性。方法 分别应用免疫组化(SP)法和流式细胞术对60例膀胱移行细胞癌组织及10例正常膀胱组织 进行Survivin蛋白检测和DNA倍体分析。结果 (1)膀胱移行细胞癌中Surv ivin的阳性表 达率和DNA异倍体率均明显高于正常膀胱组织(P<001);(2)随着膀胱移行细胞癌病理 分级、 临床分期的增高,Survivin阳性表达率和DNA异倍体率均明显升高(P<005或P<0 01);(3) 在膀胱移行细胞癌中,Survivin阳性表达率和DNA异倍体率呈正相关(P<001)。HTX K结论 Survivin阳性表达率和DNA异倍体率与膀胱癌的发生、发展及预后密切相 关。
Abstract:
Objective To investigate the expression and correlation of Sur vivin and DNA ploidy in Bladder Transitional Carcinoma Methods The im munohistochemist ry(SP method)was used to determine the expression of Survivin in 60 cases with BTCC and 10 normal bladder tissues At the same time the flow cytometry was us e d to determine DNA ploidy Results (1)The positive expression ra tes of Survivin a nd rates of DNA heteroploid in BTCC were significantly higher than those in norm al bladder tissue(P<001)(2)The positive expression rates of Survivin and rates of DNA heteroploid increased significantly with increasing pathological grade a nd clinical stage(P<005 or P<001)(3)There was a positive correla tion between the expression rates of Survivin and rates of DNA heteroploid(P<001)Conclu sion The positive expression rates of Survivin and rates of DNA heterop lo id are closely associated with tumorigenesis,progress and prognosis of BTCC

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2007-12-14 基金项目:宁夏自然科学基金资助项目 作者简介:赵瑞宁(1973-),男,山西人,主治医师,硕士,从事泌尿外科临床及 研究工作。 通信作者:陈福宝(1955-),男,宁夏人,主任医师,硕士,从事泌尿外科临床及 研究工作。
更新日期/Last Update: 2008-07-20