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[1]曹蕾,孟尽海.吗啡对垂体后叶素致兔心肌损伤的影响[J].宁夏医科大学学报,2008,(02):164-166.
 CAO Lei,MENG Jin hai.Effects of Morphine Pretreatment on Acute Myocardial Infarction Induced by Pituitrin in Rabbits[J].Ningxia Medical University,2008,(02):164-166.
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吗啡对垂体后叶素致兔心肌损伤的影响(PDF)
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《宁夏医科大学学报》[ISSN:1005-8486/CN:64-1029/R]

卷:
期数:
2008年02期
页码:
164-166
栏目:
论著
出版日期:
2008-03-20

文章信息/Info

Title:
Effects of Morphine Pretreatment on Acute Myocardial  Infarction Induced by Pituitrin in Rabbits
作者:
曹蕾孟尽海
宁夏医学院附属医院麻醉科,银川750004
Author(s):
CAO Lei MENG Jinhai
Anesthesiology Dept of the Affiliated Hospital, Ningxia Med Coll,Yinchu an 750004
关键词:
心肌损伤吗啡肌钙蛋白I双抗夹心免疫吸附法
Keywords:
myoardial infarctionmorphinetroponin Ienzyme linked immu nosorbent assayrabbit
分类号:
R363
DOI:
-
文献标志码:
A
摘要:
目的 观察吗啡预处理垂体后叶素引起的兔心肌损伤后血压、心电图和血清心肌肌 钙蛋白I(cTn-I)的含量变化,并观察心肌病理切片,探讨吗啡对受损心肌预处理的影 响。方法 将成年中国白兔24只随机分为三组,对照假手术组(A组),手 术模型完成稳定45m in后予09%生理盐水02~03mL/kg,30s静脉注射完毕;药物损伤心肌组(B组),45mi n后 予垂体后叶素(25U/kg)02~03mL/kg,30s注射完毕;吗啡预处理组(C组),予吗啡0 6 5mg/kg静脉推注,45min后予垂体后叶素(25U/kg)02~03mL/kg,30s注射完毕,记录 给药 前后平均动脉压(MAP)、中心静脉压(CVP)、HR及T波变化;测定血清cTn-I含量;观察给药 48h后白兔心肌组织的变化。结果 与A组比较,B组MAP、CVP、T波明显升 高(P<001), HR明显下降(P<001);与B组相比,C组MAP、CVP、T波明显下降(P<001),T 波B、C 组明显高于A组(P<001)。血清cTn-I水平A、C组低于B组(P<001)。 结论 吗啡预处理对垂体后叶素所致的兔心肌损伤有保护作用。
Abstract:
Objective To observe the change of blood pressure,electrocardi pgram a nd Troponin I after morphine pretreatment on acute myoardial infarction induced by pituitrin in rabbits , and to compare them with the change of pathostaining, and to explore the effect of morphine pretreatment on acute myocardial ischemic injury Methods Twentyfour rabbits were divided randomly into three groups: con trol group(Group A), pituitrin group (Group B) and morphine pretreatment group( G roup C) The information included MAP、CVP、HR and T wave were observed and rec o rded at different time points It was divided into two observing phrases of 24h , 48h and determined the contents of blood serum cTnI and caridiac pathostain of 48h Results (1) Changes in myocardiac mechanics:myocardiac mech anics had a dyna mic change after injection of pituitrin 25U/kg weight parameters between and w ithin groups throughout the experimental period except ischemia group,which had a significantl reduction in HR and a significant increase in MAP, CVP and T wav e Comared with other groups Group C compared with Group A , MAP and CVP at e ach time point there was no significant statistical difference, HR (1min) decreased (P<005),T wave increased(P<001) ComparedB group with group A, MAP (1min) s ignificantly increased (P<001), CVP significantly increased from 15 sec to 5 min (P<001), HR significantly lowered in 15sec to 10 min (P<001),T wave sign ificantly increased(P<001) Compared Group B with C group,HR significa ntly d ecreased at the point of from 30sec to 2min (P<001), MAP ,CVP and T wave was n o significant statistical difference at differnet time points (2) Blood serum c TnI showed significant difference among three groups(P<001)(3)Cardiac pathol ogical change showe significant difference among three groups Conclusion Morphine pretreatment can prevent lipid peroxidation and protect myocar dium

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2007-12-17 作者简介:曹蕾(1976-),女(回族),北京人,主治医师,在读硕士研究生, 从事临床麻碎工作。
更新日期/Last Update: 2008-03-20