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[1]郭宏伟,宋国庆,万爱玉.53例急性白血病的免疫表型分析[J].宁夏医科大学学报,2005,(04):291-293.[doi:10.3969/j.issn.1674-6309.2005.04.013]
 GUO Hong wei,SONG Guo qing,WAN Ai yu.Analysis of Immunophenotyping in Acute Leukemia in 53 Cases[J].Ningxia Medical University,2005,(04):291-293.[doi:10.3969/j.issn.1674-6309.2005.04.013]
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53例急性白血病的免疫表型分析(PDF)
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《宁夏医科大学学报》[ISSN:1005-8486/CN:64-1029/R]

卷:
期数:
2005年04期
页码:
291-293
栏目:
论著
出版日期:
2005-07-20

文章信息/Info

Title:
Analysis of Immunophenotyping in Acute Leukemia in 53 Cases
作者:
郭宏伟宋国庆万爱玉
宁夏医学院附属医院血液内科,银川750004
Author(s):
GUO HongweiSONG GuoqingWAN Aiyu
Dept of Hematology,the Affiliated Hospital of Ningxia Med Coll, Yinchuan 750004
关键词:
急性白血病免疫表型骨髓
Keywords:
acute leukemia immunophenotype bone marrow
分类号:
R733.71
DOI:
10.3969/j.issn.1674-6309.2005.04.013
文献标志码:
A
摘要:
目的探讨急性白血病(AL)的免疫表型特征。方法采用流式细胞仪对53例初治急性白血病进行免疫表型分析 。结果20例急性髓细胞白血病(AML)患者均表达两种以上髓系抗原,其中7例伴有淋系抗原(CD19、CD7)表达。32例急性淋巴细胞白 血病(ALL)患者中28例表达淋系抗原, 16例表达伴有髓系抗原(CD13、CD33、CD15);4例ALL患者为纯髓系表达(ALL23例,ALL31例)。2 例混合型白血病(AMLL)同时表达两种以上淋系和髓系抗原标志。结论白血病细胞具有高度异质性;免疫分型能确诊一些特殊类型的白 血病(Mo,AMLL),在急性白血病的诊断分型、治疗、预后判断具有重要价值;免疫分型是对细胞形态学诊断急性白血病的重要补充。
Abstract:
Objective To study the feature of immunophenotype in acute Leukemia (AL) Methods Immune phenotypes were assayed in 53 patients with acute Leukemia by flow cytometer Results All 20 AML patients expressed myeloid markers, of 7 expressed Lymphoid antigens CD7 or/and CD19 Twenty eight of ALL expressed Lymphoid antigens, of 16 expressed one or two myeloid antigens, for example CD13, CD33, CD15 Of 4 ALL cases only expressed myeloid markers (three of them were ALL2,one of them was ALL3)Two cases were hybrid acute leukemia that expressed more markers of both Lymphoid and myeloid origins Conclusion Leukemia cell has heterogeneity Leukemia immunophenotype could define some particular types of Leukemia M0 AMLL with an important value in diagnosis, treatment and predicting prognosis Immunophenotype is an important supplement to the diagnosis and typing of the acute Leukemia on the base of the morphology and cytochemistry

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2005-01-14 作者简介:郭宏伟(1969-),女,宁夏人,主治医师,学士,主要从事血液内科工作。
更新日期/Last Update: 2005-07-20