|本期目录/Table of Contents|

[1]马 坚,胡 晨,翟 堃,等.宁夏1482例先天性唇腭裂特征分析[J].宁夏医科大学学报,2019,(10):1042-1045.[doi:10.16050/j.cnki.issn1674-6309.2019.10.017]
 MA Jian,HU Chen,ZHAI Kun,et al.Retrospective Analysis of 1482 Patients with Cleft Lip and Palate in Ningxia[J].Ningxia Medical University,2019,(10):1042-1045.[doi:10.16050/j.cnki.issn1674-6309.2019.10.017]
点击复制

宁夏1482例先天性唇腭裂特征分析(PDF)
分享到:

《宁夏医科大学学报》[ISSN:1005-8486/CN:64-1029/R]

卷:
期数:
2019年10期
页码:
1042-1045
栏目:
经验交流
出版日期:
2019-11-27

文章信息/Info

Title:
Retrospective Analysis of 1482 Patients with Cleft Lip and Palate in Ningxia
文章编号:
1674-6309(2019)10-1042-04
作者:
马 坚 胡 晨 翟 堃 马 瑞 于丽丽 余 添 朱晋芳 黄永清
(宁夏医科大学总医院口腔医院口腔颌面外科,银川 750004)
Author(s):
MA Jian HU Chen ZHAI Kun MA Rui YU Lili YU Tian ZHU Jinfang HUANG Yongqing
(Department of Oral and Maxillofacial Surgery,Hospital of Stomatology,the General Hospital of Ningxia Medical University,Yinchuan 750004,China)
关键词:
目的 探讨宁夏地区先天性唇腭裂发生的特征。方法 收集宁夏地区2005年1月—2015年12月出生的唇腭裂患者相关信息将数据进行统计分析。结果 研究纳入唇腭裂患者1482例唇裂、唇裂并腭裂和腭裂三种表型分组构成分别为31.24%、45.62%和23.14%各组中性别(男:女)比为1.84、1.33和0.98回族与汉族所占比例分别为49%和51%宁夏地区唇腭裂患者60%以上分布在南部山区综合征型唇腭裂的所占总病例数的比例为2.43%其中这三组中综合征型的占比分别为2.37%、1.08%和4.37
Keywords:
cleft lippalatecleft lip and palateNingxia
分类号:
R782.2
DOI:
10.16050/j.cnki.issn1674-6309.2019.10.017
文献标志码:
B
摘要:
唇裂;腭裂;唇裂并腭裂;宁夏
Abstract:
Objective To retrospectively investigate the epidemiological characteristics of cleft lip and palate in Ningxia. Methods This study involved 1482 cases with cleft lip or palate which were born between January 2005 and December 2015 in Ningxia. Their epidemiological data were collected and analyzed. Results The proportion of the three types were 46%,31%,23%(cleft lip and palate, cleft lip, cleft palate). Gender ratios were 1.84, 1.33 and 0.98(male and female) corresponding to each group. The Hui and Han nation were constituted with a proportion of 49% and 51%. There were more than 60% cases in the southern region of Ningxia. The incidence rate of syndromic cleft was 2.43% and each group were 2.37%,1.08%,4.37%, in which the most associated abnormalities was congenital heart disease. Family history could be found in 2% patients and 90% of them occurred in the first-degree relatives. Among them, the proportions were17.39%, 69.57%, 13.04% for each groups. The cleft types were 62.50% patients with cleft lip which they inherited from their parental generation with cleft lip, 75% patients with cleft lip and palate which they were inherited from their parental generation with cleft lip and palate and 100% patients with cleft palate which they were inherited from their parental generation with cleft palate. Conclusion The incidence of cleft lip and palate in Ningxia is characterized by region, decreasing gradually from south to north, and it is more hereditary.

参考文献/References:

[1] Boo-Chai K. An ancient Chinese text on a cleft lip [J]. Plast Reconstr Surg,1966,38(2):89-91.
[2] Dixon MJ,Marazita ML,Beaty TH,et al. Cleft lip and palate:understanding genetic and environmental influences[J]. Nat Rev Genet,2011,12(3):167-178.
[3] Mossey PA,Little J. Epidemiology of oral clefts: an international perspective [M] //WYSZYNSKI DF E. Cleft lip and palate: from origin to treatment. Oxford,England;Oxford University Press. 2002:127-158.
[4] Dai L,Zhu J,Mao M,et al. Time trends in oral clefts in Chinese newborns: data from the Chinese national birth defects monitoring network[J]. Birth Defects Res Part A Clin Mol Teratol,2010,88(1):41-47.
[5] 张涛. 宁夏地区人口出生缺陷流行病学调查及相关性研究[D]. 银川: 宁夏医科大学,2013:28-30.
[6] Kling RR,Taub PJ,Ye XQ,et al. Oral clefting in China over the last decade:205,679 patients[J]. Plast Reconstr Surg Glob Open,2014,2(10):e236.
[7] Zucchero TM,Cooper ME,Maher BS,et al. Interferon regulatory factor 6(IRF6) gene variants and the risk of isolated cleft lip or palate[J]. N Engl J Med,2004,351(8):769-780.
[8] 马坚,黄永清,马敏,等. 中国西部人群IRF6基因V274I位点SNP与非综合征型唇腭裂相关性的研究[J]. 实用口腔医学杂志,2008,24(3):417-421.
[9] 马坚,黄永清,马敏,等. 宁夏人群MSX1基因CA重复序列多态性与非综合征型唇腭裂相关性的研究[J]. 现代口腔医学杂志,2009,23(4):367-369.
[10] Huang YQ,Ma J,Ma M,et al. Association between MSX1 variants and oral clefts in Han Chinese in Western China[J]. DNA Cell Biol,2011,30(12):1057-1061.
[11] Moreno Uribe LM,Fomina T,Munger RG,et al. A population-based study of effects of genetic loci on orofacial clefts[J]. J Dent Res,2017,96(11):1322-1329.
[12] de Freitas EM,Machado RA,de Moura SE,et al. Polymorphisms associated with oral clefts as potential susceptibility markers for oral and breast cancer[J]. Arch Oral Biol,2019,99:9-14.
[13] Gu M,Zhang Y,Liu HL,et al. MSH homeobox 1 polymorphisms and the risk of non-syndromic orofacial clefts:a meta-analysis[J]. Eur J Oral Sci,2018,126(3):180-185.
[14] Parada-Sanchez MT,Chu EY,Cox LL,et al. Disrupted IRF6-NME1/2 complexes as a cause of cleft lip/palate[J]. J Dent Res,2017,96(11):1330-1338.
[15] Ma J,Huang YQ,Yao C,et al. Parental health and social support in the first trimester of pregnancy and the risk of oral clefts: a questionnaire-based, case-control study[J]. Plast Reconstr Surg,2015,135(1):212-218.
[16] 于丽丽,马坚,高俊鹏,等. 宁夏地区非综合征型唇腭裂环境因素的研究[J]. 华西口腔医学杂志, 2017, 35(3):291-295.
[17] Calzolari E,Pierini A,Astolfi G,et al. Associated anomalies in multi-malformed infants with cleft lip and palate: An epidemiologic study of nearly 6 million births in 23 EUROCAT registries[J]. Am J Med Genet A,2007,143A(6):528-537.
[18] Meng T,Shi B,Zheng Q,et al. Clinical and epidemiologic studies of nonsyndromic cleft lip and palate in china: analysis of 4268 cases [J]. Ann Plast Surg,2006, 57(3):264-269.
[19] Jamilian A,Sarkarat F,Jafari M,et al. Family history and risk factors for cleft lip and palate patients and their associated anomalies[J]. Stomatologija,2017,19(3):78-83.
[20] Shkoukani M A,Chen M,Vong A. Cleft lip - a comprehensive review [J]. Frontiers in pediatrics,2013,1:53.

相似文献/References:

备注/Memo

备注/Memo:
收稿日期:2018-01-02
基金项目:国家自然科学基金(81560181);青年科学基金(81600853);宁夏回族自治区重点研发计划(2016KJHM56)
作者简介:马坚(1981-),宁夏人,博士,副主任医师,从事口腔颌面外科临床、教学及科研工作。
更新日期/Last Update: 2019-10-30