|本期目录/Table of Contents|

[1]宋晓霞,耿芝,余冰,等.VEGFR 2基因多态性与复发性自然流产的关联性研究[J].宁夏医科大学学报,2015,(11):1261-1265.[doi:10.16050/j.cnki.issn1674-6309.2015.11.004]
 SONG Xiaoxia,GENG Zhi,YU Bing,et al.-[J].Ningxia Medical University,2015,(11):1261-1265.[doi:10.16050/j.cnki.issn1674-6309.2015.11.004]
点击复制

VEGFR 2基因多态性与复发性自然流产的关联性研究(PDF)
分享到:

《宁夏医科大学学报》[ISSN:1005-8486/CN:64-1029/R]

卷:
期数:
2015年11期
页码:
1261-1265
栏目:
论著
出版日期:
2015-11-30

文章信息/Info

Title:
-
作者:
宋晓霞; 耿芝; 余冰; 盛优静; 于浩臣; 霍正浩; 陆宏;
宁夏医科大学教育部生育力保持重点实验室宁夏生殖与遗传重点实验室; 宁夏医科大学附属总院生殖医学中心; 宁夏医科大学基础学院;
Author(s):
SONG Xiaoxia;GENG Zhi;YU Bing;SHENG Youjing;YU Haochen;HUO Zhenghao;LU Hong;Key Laboratory of Fertility Peservation and Maintenance Ningxia Medical UniversityMinistry of Education Key laboratory of Reproduction and Heredity of Ningxia Hui Autonomous RegionNingxia Medical University;Department of Cell Biology and Medical GeneticsNingxia Medical University;The Center for Reproductive Medicine of General HospitalNingxia Medical University;
关键词:
血管内皮生长因子受体2 复发性自然流产 基因多态性
Keywords:
-
分类号:
R714.21
DOI:
10.16050/j.cnki.issn1674-6309.2015.11.004
文献标志码:
-
摘要:
目的探讨血管内皮生长因子受体2(vascular endothelial growth factor receptor 2,VEGFR2/KDR)基因-604T/C,+1192G/A,+1719A/T三个单核苷酸多态性位点与复发性自然流产(recurrent spontaneous abortion,RSA)的关联性。方法采用聚合酶链式反应-限制性片段长度多态性(PCR-RFLP)检测RSA组(180例,病例组)和正常对照组(191例)的VEGFR2基因3个SNPs位点基因型及等位频率分布情况。结果 VEGFR2-604T/C,+1192G/A,+1719A/T的基因型频率在病例组和对照组之间没有统计学意义(P>0.05)。VEGFR2基因+1192G/A位点等位基因分布频率在病例组和对照组间有统计学意义(P<0.01);VEGFR2基因-604T/C,+1192G/A,+1719A/T三个多态性位点所构建的TAA单倍型在病例组和正常对照组间差异有统计学意义(P<0.01)。结论携带VEGFR2+1192G等位基因的基因型可能会增加宁夏汉族女RSA的发病风险,VEGFR2-604/+1192/+1719构建的单倍型TAA与宁夏地区复发性自然流产的发病可能有关。
Abstract:
-

参考文献/References:

-

相似文献/References:

[1]邱方园,王永宁,刘贺荣,等.宁夏回汉族HSP70家族基因多态性与原发性高血压的关联研究[J].宁夏医科大学学报,2015,(12):1396.[doi:10.16050/j.cnki.issn1674-6309.2015.12.007]
 QIU Fangyuan,WANG Yongning,LIU Herong,et al.[J].Ningxia Medical University,2015,(11):1396.[doi:10.16050/j.cnki.issn1674-6309.2015.12.007]
[2]詹福寿,万艳,李霞,等.白细胞介素-10基因启动子-592 A/C多态性与 复发性自然流产的关联性研究[J].宁夏医科大学学报,2014,(10):1073.
 ZHAN Fushou,WAN Yan,LI Xia,et al.Relationship between Polymorphism of Interleukin-10 Gene Promoter -592A/C and Recurrent Spontaneous Abortion[J].Ningxia Medical University,2014,(11):1073.
[3]陈 芳,朱 红,武海亮,等.脂联素水平及其基因+45T/G和+276G/T 与原发性高血压的相关性[J].宁夏医科大学学报,2011,(11):1019.
 CHEN Fang,ZHU Hong,WU Hai-liang,et al.Correlation of the Adiponectin Level and Gene Polymorphism with the Essential Hypertension[J].Ningxia Medical University,2011,(11):1019.
[4]康毓芝,陈耀平,杨宝珍,等.宁夏汉族Graves病与CYP27B1基因 启动子-1260C/A多态性相关性研究[J].宁夏医科大学学报,2011,(06):540.
 KANG Yu-zhi,CHEN Yao-ping,YANG Bao-zhen,et al.Association between CYP27B1 Gene Promoter Polymorphisms and Patients with Graves' disease in Ningxia Han People[J].Ningxia Medical University,2011,(11):540.
[5]崔 振,杨云振,余 辉,等.16例家族性乳腺癌BRCA2基因突变的分析[J].宁夏医科大学学报,2011,(06):515.
 CUI Zhen,YANG Yun-zhen,YU Hui,et al.Analysis of the Mutations of BRCA2 Gene among Patients with Familial Breast Cancer[J].Ningxia Medical University,2011,(11):515.
[6]詹福寿,李 霞,万 艳,等.宁夏回、汉族群体IL-6启动子区基因多态性研究[J].宁夏医科大学学报,2011,(05):449.
 ZHAN Fu-shou,LI Xia,WAN Yan,et al.Gene Polymorphism in Promoter of Interleukin-6 between Hui and Han Ethnic Group of Ningxia[J].Ningxia Medical University,2011,(11):449.
[7]杨文海,王发选,杨瑾,等.TNF-α基因多态性与宁夏汉族煤工尘肺的关系[J].宁夏医科大学学报,2009,(06):758.
 YANG Wen-hai,WANG Fa-xuan,YANG Jin,et al.The Relationship Between Gene Polymorphism of TNF-α and Coal Worker Pneumoconiosis in Ningxia[J].Ningxia Medical University,2009,(11):758.
[8]贺晓莉,朱玲勤,王伟红,等.过氧化物酶体增殖物激活受体γC161→T基因多态性 与代谢综合征的相关研究[J].宁夏医科大学学报,2012,(03):204.
 HE Xiao-li,ZHU Ling-qin,WANG Wei-hong,et al.Relationship of Peroxisome Proliferator Activated Receptor Gamma C161T Gene Polymorphism with Metabolic Syndrome[J].Ningxia Medical University,2012,(11):204.
[9]郭孟境,徐惠芳,彭 亮,等.XRCC1 Arg399Gln与老年性年龄相关白内障的关联研究[J].宁夏医科大学学报,2013,(05):493.
 GUO Meng-jing,XU Hui-fang,PENG Liang,et al.Association of DNA Repair Gene XRCC1 with Senile Age- related Cataracts[J].Ningxia Medical University,2013,(11):493.
[10]王 露,金梅花,徐清斌,等.原发性高血压患者血管紧张素Ⅱ-2型受体基因C3123A 多态性及其相关因素的研究[J].宁夏医科大学学报,2013,(04):382.
 WANG Lu,JIN Mei-hua,XU Qing-bin,et al.Relationship between C3123A Polymorphism of AngiogenesisⅡ Type 2 Receptor Gene and Essential Hypertension of Hans in Ningxia[J].Ningxia Medical University,2013,(11):382.

备注/Memo

备注/Memo:
【基金】 宁夏自然科学基金(NZ14073)
更新日期/Last Update: 1900-01-01