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[1]白建平,卢建跃,孙新增,等.miR-21和miR-106a在乳腺癌组织中的表达及临床病理学意义[J].宁夏医科大学学报,2015,(05):553-556+476.[doi:10.16050/j.cnki.issn1674-6309.2015.05.020 ]
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miR-21和miR-106a在乳腺癌组织中的表达及临床病理学意义(PDF)
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《宁夏医科大学学报》[ISSN:1005-8486/CN:64-1029/R]

卷:
期数:
2015年05期
页码:
553-556+476
栏目:
经验交流
出版日期:
2015-05-30

文章信息/Info

Title:
-
作者:
白建平; 卢建跃; 孙新增; 张霆;
中国人民解放军第254医院普通外科;
Author(s):
-
关键词:
miR-21 miR-106a 乳腺癌 迁移
Keywords:
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分类号:
R737.9
DOI:
10.16050/j.cnki.issn1674-6309.2015.05.020
文献标志码:
-
摘要:
目的探讨miR-21和miR-106a与乳腺癌的表达。方法通过RT-PCR方法检测35例乳腺癌和35例乳腺良性病变组织(包括19例纤维瘤和16例乳腺腺病)中miR-21和miR-106a的表达情况,初步探讨miR-21和miR-106与乳腺癌的发生关系。并通过转染的方法将miR-21和miR-106转入乳腺癌MDA-MB231细胞中,观察其对MDA-MB231细胞迁移能力的影响。结果与乳腺良性病变组织相比,乳腺癌组织中miR-21和miR-106a的表达水平上调(P<0.01);miR-21和miR-106a的表达水平与患者M分期密切相关(P<0.05),而与患者年龄、病理分级、T分期、是否吸烟和是否饮酒均无相关关系(P均>0.05)。同时,转染miR-21和miR-106a可促进MDA-MB231细胞的迁移能力。结论 miR-21和miR-106a与乳腺癌的发生、发展密切相关。
Abstract:
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参考文献/References:

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更新日期/Last Update: 1900-01-01