|本期目录/Table of Contents|

[1]许红霞,靳雅男,赵燚,等.C反应蛋白与代谢综合征的关系[J].宁夏医科大学学报,2014,(12):1350-1352,1366.
 XU Hongxia,JIN Yanan,ZHAO Yi,et al.Distributions of C-reactive Protein and its Association with Metabolic Syndrome in Rural Residents of Ningxia[J].Ningxia Medical University,2014,(12):1350-1352,1366.
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《宁夏医科大学学报》[ISSN:1005-8486/CN:64-1029/R]

卷:
期数:
2014年12期
页码:
1350-1352,1366
栏目:
论著
出版日期:
2014-12-30

文章信息/Info

Title:
Distributions of C-reactive Protein and its Association with Metabolic Syndrome in Rural Residents of Ningxia
作者:
许红霞靳雅男赵燚王发选林虹刘秀英张毓洪
宁夏医科大学公共卫生学院,银川 750004
Author(s):
XU Hongxia JIN Yanan ZHAO Yi WANG Faxuan LIN Hong LIU Xiuying ZHANG Yuhong
School of Public Health, Ningxia Medical University, Yinchuan 750004
关键词:
C反应蛋白代谢综合征农村居民宁夏
Keywords:
C-reactive protein metabolic syndrome ruual resident Ningxia
分类号:
R446.6
DOI:
-
文献标志码:
A
摘要:
目的探讨炎症标志物C反应蛋白(C-reactiveprotein,CRP)与宁夏农村居民代谢综合征(MS)的相关关系。方法以2008-2012年参加宁夏农村居民代谢性疾病基线调查并自愿采集空腹静脉血液的550例为研究对象,双抗体夹心ELISA法检测CRP,用统计学方法进行CRP相关因素分析。结果研究样本中226例(41.09%)MS患者,324例非MS患者(58.91%);按代谢指标异常的个数划分为0个代谢指标异常组(血压、血糖、血脂均正常且无中心性肥胖)、1~2个代谢指标异常组、≥3个代谢指标异常组,CRP水平随代谢指标异常数目增加明显升高(P<0.05)。Stepwise逐步回归分析显示,影响CRP浓度的主要因素有腰围、甘油三酯和体重指数,其回归方程为:y=-12.985+0.448x1+1.282x2-0.621x3,其中y为CRP(x1为腰围,x2为甘油三酯,x3为体重指数)。结论MS者CRP水平高于无MS者;且随着代谢指标异常数的增加CRP水平逐渐升高,CRP水平升高是发生MS的危险因素。
Abstract:
Objective To explore the correlation of the inflammatory markers CRP with metabolic syndrome and its components in rural residents of Ningxia. Methods 550 cases of rural residents who were participated in the baseline survey of metabolic diseases and voluntary collected fasting venous blood during 2008-2012 were recruited and double antibody sandwich method was used for assaying the C-reactive protein. Metabloic syndrome was defined according to the International Diabetes Federation(IDF)criteria in 2005. Statistical analysis was performed using SPSS17.0.After checking for skewness and kurtosis, CRP was normalized by logarithmic transformation. Results In the study population there were 226(41.09%)MS patients, 324 non-MS patients(58.91%). The CRP level was significantly higher in subjects with Ms than those without MS(P<0.05).When divided the group scores of metabolic abnormalities into group 0(blood pressure, blood glucose, blood lipids were normal and no central obesity),one or/and two metabolic abnormalities group, three or more metabolic abnormalities group, CRP levels increased significantly with components of MS increased(P<0.05). Stepwise regression analysis showed that the main factors affecting CRP levels were waistline, triglycerides and BMI, the regression equation: y=-12.985+0.448 x1+1.282 x2-0.621x3. Conclusion The CRP level was significantly higher in subjects with MS than those without MS, and increased with components of metabolic syndrome increased. Elevated CRP levels was a risk factor for metabolic syndrome.

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备注/Memo

备注/Memo:
收稿日期:2014-03-12 基金项目:国家自然科学基金(81160358); 宁夏医科大学校级青年项目资金(XQ2012029) 作者简介:许红霞,女,讲师,研究方向:慢性病流行病学。 通信作者:张毓洪。zhabour@163.com
更新日期/Last Update: 2014-12-20