|本期目录/Table of Contents|

[1]郭孟境,徐惠芳,彭 亮,等.XRCC1 Arg399Gln与老年性年龄相关白内障的关联研究[J].宁夏医科大学学报,2013,(05):493-496.
 GUO Meng-jing,XU Hui-fang,PENG Liang,et al.Association of DNA Repair Gene XRCC1 with Senile Age- related Cataracts[J].Ningxia Medical University,2013,(05):493-496.
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XRCC1 Arg399Gln与老年性年龄相关白内障的关联研究(PDF)
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《宁夏医科大学学报》[ISSN:1005-8486/CN:64-1029/R]

卷:
期数:
2013年05期
页码:
493-496
栏目:
论著
出版日期:
2013-05-20

文章信息/Info

Title:
Association of DNA Repair Gene XRCC1 with Senile Age- related Cataracts
作者:
郭孟境1 徐惠芳2 彭 亮1 张 钏1 裴利国1 杨 帆1 霍正浩1
1.宁夏医科大学生育力保持教育部重点实验室、宁夏生殖与遗传重点实验室,银川 750004, 2.宁夏人民医院,银川 750021
Author(s):
GUO Meng-jing1 XU Hui-fang2 PENG Liang1 ZHANG Chuan1 PEI Li-guo1 YANG Fan1 HUO Zheng-hao1
1.Key Laboratory of Reproduction and Heredity of Ningxia Hui Autonomous Region, Key Laboratory of Fertility Preservation and Maintenance,Ningxia Med.Univ.,Yinchuan 750004; 2.Ningxia People's Hospital,Yinchuan 750021
关键词:
XRCC1 基因多态性 年龄相关性白内障
Keywords:
XRCC1 Gene polymorphism age related cataract
分类号:
R776.1
DOI:
-
文献标志码:
A
摘要:
目的 探讨XRCC1Arg399Gln与老年性年龄相关白内障的相关性。方法 应用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)技术检测260例年龄相关白内障患者和276例年龄相匹配正常对照者的XRCC1基因Arg399Gln。结果 病例组XRCC1Arg399Gln A等位基因频率和GA+AA基因型频率在病例组明显升高于对照组,G等位基因频率和GG基因型频率在对照组明显升高(P<0.05)。结论 XRCC1Arg399Gln与宁夏人群老年年龄相关性白内障存在关联性。
Abstract:
Objective To investigate the correlation between the XRCC1 single nucleotide polymorphisms and senile age-related cataracts. Methods XRCC1 gene polymorphisms were detected in 260 cases with senile cataract and 276 age matched normal controls by PCR-RFLP technique. Results The frequencies of genotype GA+AA and allele C at position XRCC1Arg399Gln in cased were significantly higher those in controls while G allele frequency and GG genotype were significantly increased in the control group(P<0.05). Conclusion Polymorphisms in XRCC1 Arg399Gln may be associated with the development of senile age-related cataract.

参考文献/References:

[1] Spector A,Wang GM,Kleiman NJ,et al.A brief photochemically induced oxidative insult causes irreversible lens damage and cataract.II.Mechanism of action[J].Exp Eye Res,1995,60:483-493.
[2] Sasaki H,Lin LR,Giblin FJ,et al.TEMPOL protects against lens DNA strand breaks and cataract in the X-rayed rabbit[J].Invest Ophthalmol Vis Sci,1998,39:544-552.
[3] Pendergrass W,Possin D,Wolf N,et al.Accumulation of DNA,nuclear and mitochondrial debris,and ROS at sites of age-related cortical cataract in mice[J].Invest Ophthalmol Vis Sci,2005,46:4661-4670.
[4] Hung DY,Hall J,Brennan P,et al.Genetic polymorphisms in the base excision repair pathway and cancer risk:a HuGE review[J].Am J Epidemiol,2005,162(10):925- 942.
[5] Park JY,Lee SY,Jeon HS,et al.Polymorphism of the DNA Repair Gene XRCC1 and Risk of Primary Lung Cancer[J].Cancer Epidemiol Biomark Prev,2002,11(1):23-27.
[6] Kubota Y,Nash RA,Klungland A,et al.Reconstitution of DNA base excision repair with purified human proteins:interaction between DNA polymerase beta and the XRCC1 protein[J].EMBOJ,1996,15(23):6662-6670.
[7] Padma G,Mamata M,Padma T.Polymorphisms in two DNA repair genes(XPD and XRCC1)association with age related cataracts[J].Mol Vis,2011,17:127-133.
[8] Shi YY,He L.SHEsis,a powerful software platform for analyses of linkage disequilibrium,haplotype construction,and genetic association at polymorphism loci[J].Cell Res,2005,15(2):97-98.
[9] 石莹.老年白内障患者手术前后的护理[J].中外医疗,2010,23:39-40.
[10] Vinson JA.Oxidative stress in cataracts[J].Pathophysiol,2006,13:151-162.
[11] Spector A.Oxidative stress-induced cataract:mechanism of action[J].FASEB J,1995,19:1173-1182.
[12] Yu Z,Chen J,Ford BN,et al.DNA repair systems:an overview[J].Enviro Mol Mut,1999,33(1):3-20.
[13] Siciliano MJ,Carrano AV,Thompson LH,et al.Assignment of a human DNA repair gene associated with sister chromatid exchange to chromosome 19[J].Mut Res,1986,174:303.
[14] 黄金梅,曾小云.DNA 修复基因XRCC1单核苷酸多态性与肝癌易感性[J].预防医学论坛,2010,16(5):448-451.
[15] Unal M,Batar B,Devranomlu K,et al.Polymorphisms of DNA repair genes XPD and XRCC1 and risk of cataract development[J].Exp Eye Res,2007,85(3):328-334.
[16] Luo YF,Wang BB,Qi YH,et al.Polymorphisms of the DNA repair genes XPD and XRCC1 and the risk of age-related cataract development in Han Chinese[J].Curr Eye Res,2011,36(7):632-636.

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备注/Memo

备注/Memo:
收稿日期:2013-01-05 基金项目:宁夏自然科学基金(NZ09144) 作者简介:郭孟境,男,江西人,在读硕士研究生。 通信作者:徐惠芳,女,主任医师,从事眼科临床工作。
更新日期/Last Update: 2013-05-20