|本期目录/Table of Contents|

[1]陈丽君,马蕊梅,许 旺,等.宁夏回汉族环氧化酶2-1195G>A的分析[J].宁夏医科大学学报,2012,(11):1110-1113.
 CHEN Li-jun,MA Rui-mei,XU Wang,et al.The Frequency of COX-2-1195G>A Polymorphism in Ningxia Population[J].Ningxia Medical University,2012,(11):1110-1113.
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宁夏回汉族环氧化酶2-1195G>A的分析(PDF)
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《宁夏医科大学学报》[ISSN:1005-8486/CN:64-1029/R]

卷:
期数:
2012年11期
页码:
1110-1113
栏目:
论著
出版日期:
2012-11-30

文章信息/Info

Title:
The Frequency of COX-2-1195G>A Polymorphism in Ningxia Population
作者:
陈丽君 马蕊梅 许 旺 夏春燕
宁夏银川市第一人民医院,银川 750001
Author(s):
CHEN Li-jun MA Rui-mei XU Wang XIA Chun-yan
The First People's Hospital of Yinchuan City, Yinchuan 750001
关键词:
宁夏人群 环氧化酶2-1195G>A 多态性
Keywords:
Ningxia population COX-2-1195G>A polymorphism
分类号:
Q343.1+4
DOI:
-
文献标志码:
A
摘要:
目的 探讨宁夏人群环氧化酶-2(COX-2)基因 -1195位点基因型和等位基因频率在汉、回民族和男、女性别间的分布特点。 方法 通过聚合酶链反应-限制性片段长度多态性(PCR-RFLP)技术对398例汉族和370例回族健康人群COX-2基因 -1195G>A单核苷酸多态性位点进行检测。 结果 COX-2-1195G>A基因型GG、GA、AA和等位基因G、A的分布频率在宁夏汉族人群中是14.57%、 69.35% 、16.08% 和49.25%、50.75%,在回族人群中是9.73% 、77.84% 、12.43% 和48.65%、 51.35%,宁夏回族人群COX-2-1195GA基因型频率高于汉族(P=0.025); 在宁夏男性人群中是10.76%、74.02%、15.22% 和47.77%、52.23%,在女性人群中是13.70%、72.87%、13.43% 和 50.13%、 49.87%,男、女性别间基因型和等位基因频率分布差异无统计学意义(P>0.05)。结论 宁夏回族人群携带COX-2-1195GA基因型频率多于汉族; COX-2-1195G>A基因型和等位基因频率在宁夏男、女性别间分布无统计学意义。
Abstract:
Objective To compare the difference of COX-2-1195G>A genotypes and alleles frequencies between ethnic Han and Hui, male and female in Ningxia population. Methods Single nucleotide polymorphism in COX-2-1195G>A were determined with polymerase chain reaction-restriction fragment-length polymorphism(PCR-RFLP)in 398 ethnic Han and 370 ethnic Hui healthy adults. Results The frequencies of the GG, GA, AA genotypes and G, A alleles of COX-2-1195G>A in the ethnic Han group were 14.57%, 69.35%, 16.08% and 49.25%, 50.75%, respectively, in comparison to 9.73%, 77.84%, 12.43% and 48.65%, 51.35%, respectively, in ethnic Hui group. COX-2-1195GA gentype in ethnic Hui was more than that in ethnic Han(P=0.025). These frequencies among male population were 10.76%, 74.02%, 15.22% and 47.77%, 52.23%,respectively, in comparison to 13.70%, 72.87%, 13.43% and 50.13%, 49.87%, respectively, in the female group. Conclusion Ningxia ethnic Hui individuals carried more -1195GA genotype than their Han counterparts did. The frequencies of COX-2 -1195G>A genotypes and alleles were no difference between male and female groups in NIngxia population.

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备注/Memo

备注/Memo:
收稿日期:2012-03-29 基金项目:国家自然科学基金项目(81060005); 宁夏自然科学基金项目(NZ09165) 作者简介:陈丽君。E-mail:ycchenlj@163.com
更新日期/Last Update: 2012-11-20