|本期目录/Table of Contents|

[1]韩淑霞,刘玉霞,李际春.65例卵巢恶性生殖细胞肿瘤预后相关因素分析[J].宁夏医科大学学报,2010,(04):498-500.
 HAN Shu-xia,LIU Yu-xia,LI Ji-chun.Prognostic Factors Associated with Malignant Ovarian Germ Cell Tumor among 65 Cases[J].Ningxia Medical University,2010,(04):498-500.
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65例卵巢恶性生殖细胞肿瘤预后相关因素分析(PDF)
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《宁夏医科大学学报》[ISSN:1005-8486/CN:64-1029/R]

卷:
期数:
2010年04期
页码:
498-500
栏目:
论著
出版日期:
2011-12-30

文章信息/Info

Title:
Prognostic Factors Associated with Malignant Ovarian Germ Cell Tumor among 65 Cases
作者:
韩淑霞1 刘玉霞2 李际春1
1.宁夏医科大学附属医院妇科,银川 750004; 2.宁夏回族自治区医院妇产科,银川 750021
Author(s):
HAN Shu-xia LIU Yu-xia LI Ji-chun
The Affilated Hospital of Ningxia Med. Univ., Yinchuan 750004
关键词:
卵巢恶性生殖细胞肿瘤 临床病理特征 生存率
Keywords:
malignant ovarian germ cell tumor clinic-pathologic characteristics survival rate
分类号:
R737.31
DOI:
-
文献标志码:
A
摘要:
目的 分析卵巢恶性生殖细胞肿瘤(malignant ovarian germ cell tumor, MOGCT)的病理、生存情况,探讨其预后相关因素。方法 回顾性分析1993年1月-2006年12月宁夏医科大学附属医院妇科收住的65例MOGCT患者的临床病理和随访资料,运用Kaplan-Meirer法计算术后存活率,应用Log-rank法和COX比例风险模型对可能影响MOGCT术后复发及生存的因素进行分析。结果 无性细胞瘤和未成熟性畸胎瘤是预后较好的两种病理类型,早期患者的预后好于进展期患者,无腹水和理想的减瘤术(残存瘤直径<2cm)影响预后(P<0.05),保守手术与广泛手术的生存率差异无统计学意义; 单因素分析显示:其它MOGCT、F IGOⅡ~Ⅳ期、肿瘤直径≥ 15cm、术后残瘤≥ 2cm以及术后未行标准VAC/BEP /PVB方案化疗的患者术后复发、死亡的危险性较其他患者高( P<0. 05); 多因素分析显示肿瘤≥15cm并非影响术后复发、死亡的独立因素。结论 MOGCT是一种特殊类型的卵巢恶性肿瘤。病理类型、肿瘤分期、术后残瘤大小与术后化疗是影响其预后及生存率的相关因素,其它MOGCT、F IGOⅡ~Ⅳ期、术后残瘤≥2cm等有复发危险因素的患者术后应该及时、足量地应用标准VAC/BEP /PVB方案化疗。
Abstract:
Objective To observe the clinic-pathologic characteristics and survival conditions of Malignant Ovarian Germ Cell Tumor(MOGCT)to explore the prognostic factors of MOGCT. Methods In this study, 65 cases with MOGCT who was diagnosed according to clinic-pathological characteristics in Jan 1993 in Ningxia Medical University Affiliated Hospital were followed up to November, 2006. Kaplan-Meier method was used to caculated the survival rate. Log-rank and Cox Proportional Hazards Model was used to analyse the influnence factors related with recurrence and survive. Results Dysgerminoma and immature teratoma had better prognosis than the others. The prognosis of patients at early stage was better than the patients at the advanced stage. Ascites absent and tumor-reductive surgery(the diameter of remaining<2cm)affected the prognosis. There was not significant differences in survival rate between fertility-preserving surgery and extensive surgery. In Log-rank, there were significant differences in terms of histology,F IGO stage,tumor size(<15cm vs ≥15cm),residual tumor after surgery(<2cm vs≥ 2cm)and the type of adjuvant chemotherapy implemented. In Cox analysis, except for tumor size, above all the terms were independent factors of prognostic factor. Conclusion MOGCT was one of the ovarian malignant tumor with special pathologic type. Pathologic characteristics,and FIGO stage and residual tumor after surgery and the type of adjuvant chemotherapy were independent factors associated with recurrence of MOGCT. Patients with high risks of recurrence should took full dose and cycles of standard VAC/BEP /PVB regimen.

参考文献/References:

[1] 吴小华主译. 实用妇科肿瘤学[M].4版.北京:人民卫生出版社,2002:1457-1459.
[2] Gerardo Z, Cristina B, Maria GC, et al. Survival and reproductive function after treatment of malignant germ cell ovarian tumors [J]. Journal of Clinical Oncology, 2006,19(2):1015-1020.
[3] 石一复,叶大风, 吕卫国,等.我国10288例卵巢恶性肿瘤的分布及组织学类型[J]. 中华妇产科杂志,2002,37(2):97-100.

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备注/Memo

备注/Memo:
收稿日期:2009-09-13 作者简介:韩淑霞(1976-),主治医师,从事妇科临床工作。 通信作者:李际春(1956-),主任医师,教授,硕士研究生导师。
更新日期/Last Update: 2010-04-20