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[1]张 锦,戈霞晖,杨艳娟.P21 ras、骨桥蛋白及CD44v6与肺鳞癌和腺癌关系的研究[J].宁夏医科大学学报,2010,(04):490-493,510.
 ZHANG Jin,GE Xia-hui,YANG Yan-juan.The Relationship among P21 ras, OPN and CD44v6 in Squamous Lung Cancer and Adenocarcinoma[J].Ningxia Medical University,2010,(04):490-493,510.
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P21 ras、骨桥蛋白及CD44v6与肺鳞癌和腺癌关系的研究(PDF)
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《宁夏医科大学学报》[ISSN:1005-8486/CN:64-1029/R]

卷:
期数:
2010年04期
页码:
490-493,510
栏目:
论著
出版日期:
2011-12-30

文章信息/Info

Title:
The Relationship among P21 ras, OPN and CD44v6 in Squamous Lung Cancer and Adenocarcinoma
作者:
张 锦1 戈霞晖2 杨艳娟1
1.宁夏医科大学附属医院,银川 750004; 2.第二军医大学长海医院呼吸内科,上海 200043
Author(s):
ZHANG JinGE Xia-hui YANG Yan-juan
Dept. of Respiratory Midicine, The Affilated Hospital of Ningxia Med. Univ., Yinchuan 750004
关键词:
RAS基因 OPN CD44 肺鳞癌 肺腺癌
Keywords:
RAS gene mutation osteopontin CD44v6 squamous lung cancer adenocarcinoma
分类号:
R734.2
DOI:
-
文献标志码:
A
摘要:
目的 研究P21 ras、CD44v6、骨桥蛋白(OPN)在肺鳞癌和腺癌中的表达及其与肺鳞癌和腺癌预后的相互关系。方法 应用免疫组化方法对96例非小细胞肺癌患者分别检测P21ras蛋白、CD44v6、OPN的表达,分析P21ras蛋白、CD44v6、OPN与肺癌组织学类型、分化程度、TNM分期等的关系,并通过34例随访病例了解以上指标与肺癌预后的关系。结果 ⑴中OPN 及CD44v6在鳞癌中表达率高于腺癌,而P21ras蛋白则在鳞癌及腺癌间表达差异无统计学意义,但P21ras蛋白、CD44v6、OPN三者共同表达在鳞癌则高于腺癌;(2)晚期肺癌P21ras蛋白、CD44v6、OPN的阳性表达率均显著高于早期患者,而CD44v6及OPN则在淋巴结已有转移者阳性表达率显著高于无淋巴结转移者;(3)P21ras蛋白、CD44v6、OPN阳性组累积生存率低于阴性组。结论 P21ras蛋白、CD44v6、OPN在鳞癌三者共同高表达,三者共同作用可能与肺鳞癌的发生、发展密切相关,P21ras蛋白、CD44v6、OPN的阳性表达预示着非小细胞肺癌不良预后。
Abstract:
Objective To study the expression of P21 ras, osteopontin and CD44v6 and the influences of them on prognosis in lung cancer. Methods A total of 96 patients with lung cancer were subjects The expression of P21ras, osteopontin and CD44v6 were detecte by immuno-histochemistry-staining. Then we analysed the relationship between them and some clinical parameters(including histological tumor type, differentiation and tumor stage). 35 patients out of 96 were followed up to analyze the influence of P21ras, osteopontin and CD44v6on prognosis in non-small cell lung cancer. Results ⑴ In non-small cell lung cancer,the expression of OPN and CD44v6 were more common among squamouscell carcinoma cases than them among adenocarcinoma ones, while there's no significant difference in P21ras immunoreactivity between squamous cell carcinoma and adenocarcinoma. Co-expression of RAS with OPN and CD44v6 was much higher in squamous cell carcinoma than adenocarcinoma. ⑵Compared with patients at early stage, the expression of P21ras、CD44v6 and OPN was higer than them among the patients at late stage. And CD44v6 and OPN were markedly expressed among lung cancer with lymph node metastasis than them among the patients without lymph mode metastasis. ⑶ The survival rate was lower in patients with positive expression of P21ras or CD44v6 or OPN than it in the patients with negative expression.Conclusion In non-small cell lung cancer, co-expression among P21ras, osteopontin and CD44v6 in squamous cell carcinoma maybe involved in carcinogenesis and metastasis and associated with the bad prognosis.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2009-10-01 基金项目:宁夏自然科学基金(0431) 作者简介:张锦(1959-),女,陕西人,硕士生导师,主任医师,博士,从事呼吸病学专业。
更新日期/Last Update: 2010-04-20